OBJECTIVE: To compare the proportion and rate of healing, pain, and quality of life of low-strength medical compression stockings (MCS) with traditional bandages applied for the treatment of recalcitrant venous leg ulcers. METHODS: A single-center, randomized, open-label study was performed with consecutive patients. Sigvaris prototype MCS providing 15 mm Hg-25 mm Hg at the ankle were compared with multi-layer short-stretch bandages. In both groups, pads were placed above incompetent perforating veins in the ulcer area. The initial static pressure between the dressing-covered ulcer and the pad was 29 mm Hg and 49 mm Hg with MCS and bandages, respectively. Dynamic pressure measurements showed no difference. Compression was maintained day and night and changed every week. The primary endpoint was healing within 90 days. Secondary endpoints were healing within 180 days, time to healing, pain (weekly Likert scales), and monthly quality of life (Chronic Venous Insufficiency Quality of Life [CIVIQ] questionnaire). RESULTS: Of 74 patients screened, 60 fulfilled the selection criteria and 55 completed the study; 28 in the MCS and 27 in the bandage group. Ulcers were recurrent (48%), long lasting (mean, 27 months), and large (mean, 13 cm(2)). All but one patient had deep venous reflux and/or incompetent perforating veins in addition to trunk varices. Characteristics of patients and ulcers were evenly distributed (exception: more edema in the MCS group; P =.019). Healing within 90 days was observed in 36% with MCS and in 48% with bandages (P =.350). Healing within 180 days was documented in 50% with MCS and in 67% with bandages (P =.210). Time to healing was identical. Pain scored 44 and 46 initially (on a scale in which 100 referred to maximum and 0 to no pain) and decreased within the first week to 20 and 28 in the MCS and bandage groups, respectively (P <.001 vs .010). Quality of life showed no difference between the treatment groups. In both groups, pain at 90 days had decreased by half, independent of completion of healing. Physical, social, and psychic impairment improved significantly in patients with healed ulcers only. CONCLUSION: Our study illustrates the difficulty of bringing large and long-standing venous ulcers to heal. The effect of compression with MCS was not different from that of compression with bandages. Both treatments alleviated pain promptly. Quality of life was improved only in patients whose ulcers had healed.

Background. Evening edema of the legs is a physiologic phenomenon occurring after sitting and standing. Objective. The objective of this study was to investigate which compression pressure is necessary to prevent leg swelling. Methods. In 12 volunteers, the volume of both lower legs was measured in the morning and 7 h later, the difference being defined as evening edema (mL). The procedure was carried out for 4 days, in which the subjects wore below-knee stockings of different compression levels alternatively on one leg only in a random order. Compression pressure was assessed using the HATRA device. Results. The average evening edema of the noncompressed legs was 62.4 mL on the left side and 94.4 mL on the right side (n.s.). Evening edema was significantly reduced to 40.3 mL by light support stockings, to -34.1 mL by compression class A, to -39.6 by compression class I, and to -59.1 mL by compression class II. Mainly stockings exerting a pressure above 10 mmHg improved subjective symptoms. Conclusion. Calf-length compression stockings with a pressure range between 11 and 21 mmHg are able to reduce or totally prevent evening edema and may therefore be recommended for people with a profession connected with long periods of sitting or standing. HUGO PARTSCH, MD, JOHANN WINIGER, AND BERTRAND LUN HAVE INDICATED NO SIGNIFICANT INTEREST WITH COMMERCIAL SUPPORTERS.

Background. Evening edema of the legs is a physiologic phenomenon occurring after sitting and standing. Objective. The objective of this study was to investigate which compression pressure is necessary to prevent leg swelling. Methods. In 12 volunteers, the volume of both lower legs was measured in the morning and 7 h later, the difference being defined as evening edema (mL). The procedure was carried out for 4 days, in which the subjects wore below-knee stockings of different compression levels alternatively on one leg only in a random order. Compression pressure was assessed using the HATRA device. Results. The average evening edema of the noncompressed legs was 62.4 mL on the left side and 94.4 mL on the right side (n.s.). Evening edema was significantly reduced to 40.3 mL by light support stockings, to -34.1 mL by compression class A, to -39.6 by compression class I, and to -59.1 mL by compression class II. Mainly stockings exerting a pressure above 10 mmHg improved subjective symptoms. Conclusion. Calf-length compression stockings with a pressure range between 11 and 21 mmHg are able to reduce or totally prevent evening edema and may therefore be recommended for people with a profession connected with long periods of sitting or standing. HUGO PARTSCH, MD, JOHANN WINIGER, AND BERTRAND LUN HAVE INDICATED NO SIGNIFICANT INTEREST WITH COMMERCIAL SUPPORTERS.