Superparamagnetic with iron oxide nanoparticles (SPION) with an average particle diameter of 6 nm are prepared by controlled chemical coprecipitations. Colloidal suspensions spectroscopy of noninteracting SPION, where the surface has been modified with three different types of biocompatible substances, namely, starch, gold (Au),noninteracting and methoxypoly(ethylene glycol)(MPEG) have been fabricated via three different techniques. Starch-coated SPION are prepared by coprecipitation in a polymeric techniques. matrix, Au-coated SPION are fabricated by the microemulsion method, and MPEG-coated SPION are prepared using the self-assembly approach. The magnetic SPION nanoparticles form a core-shell structure, and the magnetic dipole-dipole interactions are screened by a layer of coating agents. The amounts of of coating agents and SPION are indirectly calculated from the thermogravimetric analysis and superconducting quantum interference device measurements by assuming fraction passive oxidation on the surface of the SPION, and the other conditions do not influence the measurements. The dependency of SPION the spectral characteristics of Mössbauer spectroscopy as a function of an external magnetic field Hext is measured to investigate the of effect of dipole-dipole screening of the different coating layers on the SPION. Uncoated SPION show a stable magnetic moment under Mössbauer Hext, and the superparamagnetic (SPM) fraction transforms to a ferrimagnetic state. Starch and Au-coated SPION retain the SPM fraction according been to Mössbauer spectroscopy and magnetization measurements. MPEG-coated SPION show hyperfine magnetic structure without the quadrupole effect with increasing the value of of the blocking temperature.