| author name | recommending | commenting | favorite | papers | recom. | cited | |
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| 0 | 0 | 0 | 53 | 0 | 331 | [Update] | |
| 0 | 0 | 0 | 1 | 0 | 0 | [Update] | |
| 0 | 0 | 0 | 2 | 0 | 23 | [Update] | |
| 0 | 0 | 0 | 4 | 0 | 80 | [Update] | |
| 0 | 0 | 0 | 1 | 0 | 0 | [Update] | |
| 0 | 0 | 0 | 1 | 0 | 0 | [Update] | |
| 0 | 0 | 0 | 1 | 0 | 8 | [Update] | |
| 0 | 0 | 0 | 1 | 0 | 0 | [Update] | |
| 0 | 0 | 0 | 1 | 0 | 6 | [Update] | |
| 0 | 0 | 0 | 1 | 0 | 0 | [Update] | |
| 0 | 0 | 0 | 1 | 0 | 0 | [Update] | |
| 0 | 0 | 0 | 1 | 0 | 1 | [Update] | |
| 0 | 0 | 0 | 1 | 0 | 8 | [Update] | |
| 0 | 0 | 0 | 2 | 0 | 5 | [Update] | |
| 0 | 0 | 0 | 9 | 0 | 133 | [Update] | |
| 0 | 0 | 0 | 1 | 0 | 1 | [Update] | |
| 0 | 0 | 0 | 2 | 0 | 2 | [Update] | |
| 0 | 0 | 0 | 3 | 0 | 149 | [Update] | |
| 0 | 0 | 0 | 4 | 0 | 13 | [Update] | |
| 0 | 0 | 0 | 1 | 0 | 1 | [Update] | |
| 0 | 0 | 0 | 1 | 0 | 3 | [Update] |
Latest Paper:
J Virol. 2012 Mar 21;:
22438556
Matthew D Greseth,
Kathleen A Boyle,
Matthew S Bluma,
Bethany Unger,
Matthew S Wiebe,
Jamaria A Soares-Martins,
Nadi T Wickramasekera,
James Wahlberg,
Paula Traktman
Department of Microbiology & Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI 53226.
Vaccinia virus, the prototypic poxvirus, efficiently and faithfully replicates its ∼200 kb DNA genome within the cytoplasm of infected cells. This intracellular localization dictates that vaccinia encodes most, if not all, of its own DNA replication machinery. Included in the repertoire of viral replication proteins is the I3 protein, which binds to ssDNA with great specificity and stability and has been presumed to be the replicative SSB. We substantiate here that I3 co-localizes with BrdU-labeled nascent viral genomes, and that these genomes accumulate in cytoplasmic factories that are delimited by membranes derived from the endoplasmic reticulum. Moreover, we report on a structure/function analysis of I3 involving the isolation and characterization of 10 clustered-charge-to-alanine mutants. These mutants were analyzed for their biochemical properties (self-interaction and DNA binding) and biological competence. Three of the mutant proteins, I3-4,-5 and -7, were deficient in self-interaction and unable to support virus viability, strongly suggesting that the multimerization of I3 is biologically significant. Mutant I3-5 was also deficient in DNA binding. Additionally, we demonstrate that siRNA-mediated depletion of I3 causes a significant decrease in the accumulation of progeny genomes, and that this reduction diminishes the yield of infectious virus.
Colorectal Dis. 2012 Mar 5;:
22390478
School of Medicine, University of Leeds, Leeds, UK Department of Colorectal Surgery, Leeds General Infirmary, Leeds, UK.
Aim: the response of rectal adenocarcinoma to neoadjuvant therapy is variable. Accurate prediction of response would enable selective administration of therapy. The enzyme glutathione S-transferase Pi (GSTP1) has been shown to influence response to therapy in some solid tumours. Few data are available for rectal cancer. Method: GSTP1 levels in rectal adenocarcinoma and adjacent normal mucosa were quantified before and after exposure to neoadjuvant therapy. Venous blood samples and biopsies of normal rectal mucosa and tumour were prospectively obtained from patients with primary rectal cancer. Patients were stratified by exposure to neoadjuvant therapy or surgery alone. GSTP1 was quantitatively measured using an enzyme-linked immunosorbent assay. Results: ninety two (54 male; median age 68 years) patients were recruited. GSTP1 was significantly greater in rectal adenocarcinoma compared with matched normal mucosa [median 6.59 vs. 4.57 μg/mg, p<0.001]. Tumour GSTP1 was significantly lower in the therapy group compared with unmatched samples from the no therapy group [median 4.47 vs. 7.76 μg/mg, p<0.001]. Conclusion: GSTP1 is increased in rectal adenocarcinoma compared with adjacent normal mucosa. It decreases following neoadjuvant therapy. © 2012 The Authors Colorectal Disease © 2012 The Association of Coloproctology of Great Britain and Ireland.
A Adare,
S Afanasiev,
C Aidala,
N N Ajitanand,
Y Akiba,
H Al-Bataineh,
J Alexander,
K Aoki,
Y Aramaki,
E T Atomssa,
R Averbeck,
T C Awes,
B Azmoun,
V Babintsev,
M Bai,
G Baksay,
L Baksay,
K N Barish,
B Bassalleck,
A T Basye,
S Bathe,
V Baublis,
C Baumann,
A Bazilevsky,
S Belikov,
R Belmont,
R Bennett,
A Berdnikov,
Y Berdnikov,
A A Bickley,
J S Bok,
K Boyle,
M L Brooks,
H Buesching,
V Bumazhnov,
G Bunce,
S Butsyk,
C M Camacho,
S Campbell,
C-H Chen,
C Y Chi,
M Chiu,
I J Choi,
R K Choudhury,
P Christiansen,
T Chujo,
P Chung,
O Chvala,
V Cianciolo,
Z Citron,
B A Cole,
M Connors,
P Constantin,
M Csanád,
T Csörgő,
T Dahms,
S Dairaku,
I Danchev,
K Das,
A Datta,
G David,
A Denisov,
A Deshpande,
E J Desmond,
O Dietzsch,
A Dion,
M Donadelli,
O Drapier,
A Drees,
K A Drees,
J M Durham,
A Durum,
D Dutta,
S Edwards,
Y V Efremenko,
F Ellinghaus,
T Engelmore,
A Enokizono,
H En'yo,
S Esumi,
B Fadem,
D E Fields,
M Finger,
M Finger Jr,
F Fleuret,
S L Fokin,
Z Fraenkel,
J E Frantz,
A Franz,
A D Frawley,
K Fujiwara,
Y Fukao,
T Fusayasu,
I Garishvili,
A Glenn,
H Gong,
M Gonin,
Y Goto,
R Granier de Cassagnac,
N Grau,
S V Greene,
M Grosse Perdekamp,
T Gunji,
H-Å Gustafsson,
J S Haggerty,
K I Hahn,
H Hamagaki,
J Hamblen,
R Han,
J Hanks,
E P Hartouni,
E Haslum,
R Hayano,
X He,
M Heffner,
T K Hemmick,
T Hester,
J C Hill,
M Hohlmann,
W Holzmann,
K Homma,
B Hong,
T Horaguchi,
D Hornback,
S Huang,
T Ichihara,
R Ichimiya,
J Ide,
Y Ikeda,
K Imai,
M Inaba,
D Isenhower,
M Ishihara,
T Isobe,
M Issah,
A Isupov,
D Ivanischev,
B V Jacak,
J Jia,
J Jin,
B M Johnson,
K S Joo,
D Jouan,
D S Jumper,
F Kajihara,
S Kametani,
N Kamihara,
J Kamin,
J H Kang,
J Kapustinsky,
K Karatsu,
D Kawall,
M Kawashima,
A V Kazantsev,
T Kempel,
A Khanzadeev,
K M Kijima,
B I Kim,
D H Kim,
D J Kim,
E Kim,
E J Kim,
S H Kim,
Y J Kim,
E Kinney,
K Kiriluk,
A Kiss,
E Kistenev,
L Kochenda,
B Komkov,
M Konno,
J Koster,
D Kotchetkov,
A Kozlov,
A Král,
A Kravitz,
G J Kunde,
K Kurita,
M Kurosawa,
Y Kwon,
G S Kyle,
R Lacey,
Y S Lai,
J G Lajoie,
A Lebedev,
D M Lee,
J Lee,
K Lee,
K B Lee,
K S Lee,
M J Leitch,
M A L Leite,
E Leitner,
B Lenzi,
X Li,
P Liebing,
L A Linden Levy,
T Liška,
A Litvinenko,
H Liu,
M X Liu,
B Love,
R Luechtenborg,
D Lynch,
C F Maguire,
Y I Makdisi,
A Malakhov,
M D Malik,
V I Manko,
E Mannel,
Y Mao,
H Masui,
F Matathias,
M McCumber,
P L McGaughey,
N Means,
B Meredith,
Y Miake,
A C Mignerey,
P Mikeš,
K Miki,
A Milov,
M Mishra,
J T Mitchell,
A K Mohanty,
Y Morino,
A Morreale,
D P Morrison,
T V Moukhanova,
J Murata,
S Nagamiya,
J L Nagle,
M Naglis,
M I Nagy,
I Nakagawa,
Y Nakamiya,
T Nakamura,
K Nakano,
J Newby,
M Nguyen,
R Nouicer,
A S Nyanin,
E O'Brien,
S X Oda,
C A Ogilvie,
M Oka,
K Okada,
Y Onuki,
A Oskarsson,
M Ouchida,
K Ozawa,
R Pak,
V Pantuev,
V Papavassiliou,
I H Park,
J Park,
S K Park,
W J Park,
S F Pate,
H Pei,
J-C Peng,
H Pereira,
V Peresedov,
D Yu Peressounko,
C Pinkenburg,
R P Pisani,
M Proissl,
M L Purschke,
A K Purwar,
H Qu,
J Rak,
A Rakotozafindrabe,
I Ravinovich,
K F Read,
K Reygers,
V Riabov,
Y Riabov,
E Richardson,
D Roach,
G Roche,
S D Rolnick,
M Rosati,
C A Rosen,
S S E Rosendahl,
P Rosnet,
P Rukoyatkin,
P Ružička,
B Sahlmueller,
N Saito,
T Sakaguchi,
K Sakashita,
V Samsonov,
S Sano,
T Sato,
S Sawada,
K Sedgwick,
J Seele,
R Seidl,
A Yu Semenov,
R Seto,
D Sharma,
I Shein,
T-A Shibata,
K Shigaki,
M Shimomura,
K Shoji,
P Shukla,
A Sickles,
C L Silva,
D Silvermyr,
C Silvestre,
K S Sim,
B K Singh,
C P Singh,
V Singh,
M Slunečka,
R A Soltz,
W E Sondheim,
S P Sorensen,
I V Sourikova,
N A Sparks,
P W Stankus,
E Stenlund,
S P Stoll,
T Sugitate,
A Sukhanov,
J Sziklai,
E M Takagui,
A Taketani,
R Tanabe,
Y Tanaka,
K Tanida,
M J Tannenbaum,
S Tarafdar,
A Taranenko,
P Tarján,
H Themann,
T L Thomas,
M Togawa,
A Toia,
L Tomášek,
H Torii,
R S Towell,
I Tserruya,
Y Tsuchimoto,
C Vale,
H Valle,
H W van Hecke,
E Vazquez-Zambrano,
A Veicht,
J Velkovska,
R Vértesi,
A A Vinogradov,
M Virius,
V Vrba,
E Vznuzdaev,
X R Wang,
D Watanabe,
K Watanabe,
Y Watanabe,
F Wei,
R Wei,
J Wessels,
S N White,
D Winter,
J P Wood,
C L Woody,
R M Wright,
M Wysocki,
W Xie,
Y L Yamaguchi,
K Yamaura,
R Yang,
A Yanovich,
J Ying,
S Yokkaichi,
Z You,
G R Young,
I Younus,
I E Yushmanov,
W A Zajc,
C Zhang,
S Zhou,
L Zolin
University of Colorado, Boulder, Colorado 80309, USA.
Flow coefficients v_{n} for n=2, 3, 4, characterizing the anisotropic collective flow in Au+Au collisions at sqrt[s_{NN}]=200 GeV, are measured relative to event planes Ψ_{n}, determined at large rapidity. We report v_{n} as a function of transverse momentum and collision centrality, and study the correlations among the event planes of different order n. The v_{n} are well described by hydrodynamic models which employ a Glauber Monte Carlo initial state geometry with fluctuations, providing additional constraining power on the interplay between initial conditions and the effects of viscosity as the system evolves. This new constraint can serve to improve the precision of the extracted shear viscosity to entropy density ratio η/s.
A Adare,
S Afanasiev,
C Aidala,
N N Ajitanand,
Y Akiba,
H Al-Bataineh,
J Alexander,
A Angerami,
K Aoki,
N Apadula,
Y Aramaki,
E T Atomssa,
R Averbeck,
T C Awes,
B Azmoun,
V Babintsev,
M Bai,
G Baksay,
L Baksay,
K N Barish,
B Bassalleck,
A T Basye,
S Bathe,
V Baublis,
C Baumann,
A Bazilevsky,
S Belikov,
R Belmont,
R Bennett,
A Berdnikov,
Y Berdnikov,
J H Bhom,
D S Blau,
J S Bok,
K Boyle,
M L Brooks,
H Buesching,
V Bumazhnov,
G Bunce,
S Butsyk,
S Campbell,
A Caringi,
C-H Chen,
C Y Chi,
M Chiu,
I J Choi,
J B Choi,
R K Choudhury,
P Christiansen,
T Chujo,
P Chung,
O Chvala,
V Cianciolo,
Z Citron,
B A Cole,
Z Conesa Del Valle,
M Connors,
M Csanád,
T Csörgő,
T Dahms,
S Dairaku,
I Danchev,
K Das,
A Datta,
G David,
M K Dayananda,
A Denisov,
A Deshpande,
E J Desmond,
K V Dharmawardane,
O Dietzsch,
A Dion,
M Donadelli,
O Drapier,
A Drees,
K A Drees,
J M Durham,
A Durum,
D Dutta,
L D'Orazio,
S Edwards,
Y V Efremenko,
F Ellinghaus,
T Engelmore,
A Enokizono,
H En'yo,
S Esumi,
B Fadem,
D E Fields,
M Finger,
M Finger Jr,
F Fleuret,
S L Fokin,
Z Fraenkel,
J E Frantz,
A Franz,
A D Frawley,
K Fujiwara,
Y Fukao,
T Fusayasu,
I Garishvili,
A Glenn,
H Gong,
M Gonin,
Y Goto,
R Granier de Cassagnac,
N Grau,
S V Greene,
G Grim,
M Grosse Perdekamp,
T Gunji,
H-Å Gustafsson,
J S Haggerty,
K I Hahn,
H Hamagaki,
J Hamblen,
R Han,
J Hanks,
E Haslum,
R Hayano,
X He,
M Heffner,
T K Hemmick,
T Hester,
J C Hill,
M Hohlmann,
W Holzmann,
K Homma,
B Hong,
T Horaguchi,
D Hornback,
S Huang,
T Ichihara,
R Ichimiya,
Y Ikeda,
K Imai,
M Inaba,
D Isenhower,
M Ishihara,
M Issah,
A Isupov,
D Ivanischev,
Y Iwanaga,
B V Jacak,
J Jia,
X Jiang,
J Jin,
B M Johnson,
T Jones,
K S Joo,
D Jouan,
D S Jumper,
F Kajihara,
J Kamin,
J H Kang,
J Kapustinsky,
K Karatsu,
M Kasai,
D Kawall,
M Kawashima,
A V Kazantsev,
T Kempel,
A Khanzadeev,
K M Kijima,
J Kikuchi,
A Kim,
B I Kim,
D J Kim,
E J Kim,
Y-J Kim,
E Kinney,
A Kiss,
E Kistenev,
L Kochenda,
B Komkov,
M Konno,
J Koster,
A Král,
A Kravitz,
G J Kunde,
K Kurita,
M Kurosawa,
Y Kwon,
G S Kyle,
R Lacey,
Y S Lai,
J G Lajoie,
A Lebedev,
D M Lee,
J Lee,
K B Lee,
K S Lee,
M J Leitch,
M A L Leite,
X Li,
P Lichtenwalner,
P Liebing,
L A Linden Levy,
T Liška,
A Litvinenko,
H Liu,
M X Liu,
B Love,
D Lynch,
C F Maguire,
Y I Makdisi,
A Malakhov,
M D Malik,
V I Manko,
E Mannel,
Y Mao,
H Masui,
F Matathias,
M McCumber,
P L McGaughey,
N Means,
B Meredith,
Y Miake,
T Mibe,
A C Mignerey,
K Miki,
A Milov,
J T Mitchell,
A K Mohanty,
H J Moon,
Y Morino,
A Morreale,
D P Morrison,
T V Moukhanova,
T Murakami,
J Murata,
S Nagamiya,
J L Nagle,
M Naglis,
M I Nagy,
I Nakagawa,
Y Nakamiya,
K R Nakamura,
T Nakamura,
K Nakano,
S Nam,
J Newby,
M Nguyen,
M Nihashi,
R Nouicer,
A S Nyanin,
C Oakley,
E O'Brien,
S X Oda,
C A Ogilvie,
M Oka,
K Okada,
Y Onuki,
A Oskarsson,
M Ouchida,
K Ozawa,
R Pak,
V Pantuev,
V Papavassiliou,
I H Park,
S K Park,
W J Park,
S F Pate,
H Pei,
J-C Peng,
H Pereira,
V Peresedov,
D Yu Peressounko,
R Petti,
C Pinkenburg,
R P Pisani,
M Proissl,
M L Purschke,
H Qu,
J Rak,
I Ravinovich,
K F Read,
K Reygers,
V Riabov,
Y Riabov,
E Richardson,
D Roach,
G Roche,
S D Rolnick,
M Rosati,
C A Rosen,
S S E Rosendahl,
P Rukoyatkin,
P Ružička,
B Sahlmueller,
N Saito,
T Sakaguchi,
K Sakashita,
V Samsonov,
S Sano,
T Sato,
S Sawada,
K Sedgwick,
J Seele,
R Seidl,
R Seto,
D Sharma,
I Shein,
T-A Shibata,
K Shigaki,
M Shimomura,
K Shoji,
P Shukla,
A Sickles,
C L Silva,
D Silvermyr,
C Silvestre,
K S Sim,
B K Singh,
C P Singh,
V Singh,
M Slunečka,
R A Soltz,
W E Sondheim,
S P Sorensen,
I V Sourikova,
P W Stankus,
E Stenlund,
S P Stoll,
T Sugitate,
A Sukhanov,
J Sziklai,
E M Takagui,
A Taketani,
R Tanabe,
Y Tanaka,
S Taneja,
K Tanida,
M J Tannenbaum,
S Tarafdar,
A Taranenko,
H Themann,
D Thomas,
T L Thomas,
M Togawa,
A Toia,
L Tomášek,
H Torii,
R S Towell,
I Tserruya,
Y Tsuchimoto,
C Vale,
H Valle,
H W van Hecke,
E Vazquez-Zambrano,
A Veicht,
J Velkovska,
R Vértesi,
M Virius,
V Vrba,
E Vznuzdaev,
X R Wang,
D Watanabe,
K Watanabe,
Y Watanabe,
F Wei,
R Wei,
J Wessels,
S N White,
D Winter,
C L Woody,
R M Wright,
M Wysocki,
Y L Yamaguchi,
K Yamaura,
R Yang,
A Yanovich,
J Ying,
S Yokkaichi,
Z You,
G R Young,
I Younus,
I E Yushmanov,
W A Zajc,
S Zhou,
L Zolin
University of Colorado, Boulder, Colorado 80309, USA.
Back-to-back hadron pair yields in d+Au and p+p collisions at sqrt[s_{NN}]=200 GeV were measured with the PHENIX detector at the Relativistic Heavy Ion Collider. Rapidity separated hadron pairs were detected with the trigger hadron at pseudorapidity |η|<0.35 and the associated hadron at forward rapidity (deuteron direction, 3.0<η<3.8). Pairs were also detected with both hadrons measured at forward rapidity; in this case, the yield of back-to-back hadron pairs in d+Au collisions with small impact parameters is observed to be suppressed by a factor of 10 relative to p+p collisions. The kinematics of these pairs is expected to probe partons in the Au nucleus with a low fraction x of the nucleon momenta, where the gluon densities rise sharply. The observed suppression as a function of nuclear thickness, p_{T}, and η points to cold nuclear matter effects arising at high parton densities.
A Adare,
S Afanasiev,
C Aidala,
N N Ajitanand,
Y Akiba,
H Al-Bataineh,
J Alexander,
A Angerami,
K Aoki,
N Apadula,
L Aphecetche,
Y Aramaki,
J Asai,
E T Atomssa,
R Averbeck,
T C Awes,
B Azmoun,
V Babintsev,
M Bai,
G Baksay,
L Baksay,
A Baldisseri,
K N Barish,
P D Barnes,
B Bassalleck,
A T Basye,
S Bathe,
S Batsouli,
V Baublis,
C Baumann,
A Bazilevsky,
S Belikov,
R Belmont,
R Bennett,
A Berdnikov,
Y Berdnikov,
J H Bhom,
A A Bickley,
D S Blau,
J G Boissevain,
J S Bok,
H Borel,
K Boyle,
M L Brooks,
H Buesching,
V Bumazhnov,
G Bunce,
S Butsyk,
C M Camacho,
S Campbell,
A Caringi,
B S Chang,
W C Chang,
J-L Charvet,
C-H Chen,
S Chernichenko,
C Y Chi,
M Chiu,
I J Choi,
J B Choi,
R K Choudhury,
P Christiansen,
T Chujo,
P Chung,
A Churyn,
O Chvala,
V Cianciolo,
Z Citron,
B A Cole,
Z Conesa Del Valle,
M Connors,
P Constantin,
M Csanád,
T Csörgő,
T Dahms,
S Dairaku,
I Danchev,
K Das,
A Datta,
G David,
M K Dayananda,
A Denisov,
D d'Enterria,
A Deshpande,
E J Desmond,
K V Dharmawardane,
O Dietzsch,
A Dion,
M Donadelli,
O Drapier,
A Drees,
K A Drees,
A K Dubey,
J M Durham,
A Durum,
D Dutta,
V Dzhordzhadze,
L D'Orazio,
S Edwards,
Y V Efremenko,
F Ellinghaus,
T Engelmore,
A Enokizono,
H En'yo,
S Esumi,
K O Eyser,
B Fadem,
D E Fields,
M Finger,
M Finger Jr,
F Fleuret,
S L Fokin,
Z Fraenkel,
J E Frantz,
A Franz,
A D Frawley,
K Fujiwara,
Y Fukao,
T Fusayasu,
I Garishvili,
A Glenn,
H Gong,
M Gonin,
J Gosset,
Y Goto,
R Granier de Cassagnac,
N Grau,
S V Greene,
G Grim,
M Grosse Perdekamp,
T Gunji,
H-Å Gustafsson,
A Hadj Henni,
J S Haggerty,
K I Hahn,
H Hamagaki,
J Hamblen,
R Han,
J Hanks,
E P Hartouni,
K Haruna,
E Haslum,
R Hayano,
X He,
M Heffner,
T K Hemmick,
T Hester,
J C Hill,
M Hohlmann,
W Holzmann,
K Homma,
B Hong,
T Horaguchi,
D Hornback,
S Huang,
T Ichihara,
R Ichimiya,
H Iinuma,
Y Ikeda,
K Imai,
J Imrek,
M Inaba,
D Isenhower,
M Ishihara,
T Isobe,
M Issah,
A Isupov,
D Ivanischev,
Y Iwanaga,
B V Jacak,
J Jia,
X Jiang,
J Jin,
B M Johnson,
T Jones,
K S Joo,
D Jouan,
D S Jumper,
F Kajihara,
S Kametani,
N Kamihara,
J Kamin,
J H Kang,
J Kapustinsky,
K Karatsu,
M Kasai,
D Kawall,
M Kawashima,
A V Kazantsev,
T Kempel,
A Khanzadeev,
K M Kijima,
J Kikuchi,
A Kim,
B I Kim,
D H Kim,
D J Kim,
E Kim,
E J Kim,
S H Kim,
Y-J Kim,
E Kinney,
K Kiriluk,
A Kiss,
E Kistenev,
J Klay,
C Klein-Boesing,
L Kochenda,
B Komkov,
M Konno,
J Koster,
A Kozlov,
A Král,
A Kravitz,
G J Kunde,
K Kurita,
M Kurosawa,
M J Kweon,
Y Kwon,
G S Kyle,
R Lacey,
Y S Lai,
J G Lajoie,
D Layton,
A Lebedev,
D M Lee,
J Lee,
K B Lee,
K S Lee,
T Lee,
M J Leitch,
M A L Leite,
B Lenzi,
X Li,
P Lichtenwalner,
P Liebing,
L A Linden Levy,
T Liška,
A Litvinenko,
H Liu,
M X Liu,
B Love,
D Lynch,
C F Maguire,
Y I Makdisi,
A Malakhov,
M D Malik,
V I Manko,
E Mannel,
Y Mao,
L Mašek,
H Masui,
F Matathias,
M McCumber,
P L McGaughey,
D McGlinchey,
N Means,
B Meredith,
Y Miake,
T Mibe,
A C Mignerey,
P Mikeš,
K Miki,
A Milov,
M Mishra,
J T Mitchell,
A K Mohanty,
H J Moon,
Y Morino,
A Morreale,
D P Morrison,
T V Moukhanova,
D Mukhopadhyay,
T Murakami,
J Murata,
S Nagamiya,
J L Nagle,
M Naglis,
M I Nagy,
I Nakagawa,
Y Nakamiya,
K R Nakamura,
T Nakamura,
K Nakano,
S Nam,
J Newby,
M Nguyen,
M Nihashi,
T Niita,
R Nouicer,
A S Nyanin,
C Oakley,
E O'Brien,
S X Oda,
C A Ogilvie,
M Oka,
K Okada,
Y Onuki,
A Oskarsson,
M Ouchida,
K Ozawa,
R Pak,
A P T Palounek,
V Pantuev,
V Papavassiliou,
I H Park,
J Park,
S K Park,
W J Park,
S F Pate,
H Pei,
J-C Peng,
H Pereira,
V Peresedov,
D Yu Peressounko,
R Petti,
C Pinkenburg,
R P Pisani,
M Proissl,
M L Purschke,
A K Purwar,
H Qu,
J Rak,
A Rakotozafindrabe,
I Ravinovich,
K F Read,
S Rembeczki,
K Reygers,
V Riabov,
Y Riabov,
E Richardson,
D Roach,
G Roche,
S D Rolnick,
M Rosati,
C A Rosen,
S S E Rosendahl,
P Rosnet,
P Rukoyatkin,
P Ružička,
V L Rykov,
B Sahlmueller,
N Saito,
T Sakaguchi,
S Sakai,
K Sakashita,
V Samsonov,
S Sano,
T Sato,
S Sawada,
K Sedgwick,
J Seele,
R Seidl,
A Yu Semenov,
V Semenov,
R Seto,
D Sharma,
I Shein,
T-A Shibata,
K Shigaki,
M Shimomura,
K Shoji,
P Shukla,
A Sickles,
C L Silva,
D Silvermyr,
C Silvestre,
K S Sim,
B K Singh,
C P Singh,
V Singh,
M Slunečka,
A Soldatov,
R A Soltz,
W E Sondheim,
S P Sorensen,
I V Sourikova,
F Staley,
P W Stankus,
E Stenlund,
M Stepanov,
A Ster,
S P Stoll,
T Sugitate,
C Suire,
A Sukhanov,
J Sziklai,
E M Takagui,
A Taketani,
R Tanabe,
Y Tanaka,
S Taneja,
K Tanida,
M J Tannenbaum,
S Tarafdar,
A Taranenko,
P Tarján,
H Themann,
D Thomas,
T L Thomas,
M Togawa,
A Toia,
L Tomášek,
Y Tomita,
H Torii,
R S Towell,
V-N Tram,
I Tserruya,
Y Tsuchimoto,
C Vale,
H Valle,
H W van Hecke,
E Vazquez-Zambrano,
A Veicht,
J Velkovska,
R Vértesi,
A A Vinogradov,
M Virius,
A Vossen,
V Vrba,
E Vznuzdaev,
X R Wang,
D Watanabe,
K Watanabe,
Y Watanabe,
F Wei,
R Wei,
J Wessels,
S N White,
D Winter,
C L Woody,
R M Wright,
M Wysocki,
W Xie,
Y L Yamaguchi,
K Yamaura,
R Yang,
A Yanovich,
J Ying,
S Yokkaichi,
Z You,
G R Young,
I Younus,
I E Yushmanov,
W A Zajc,
O Zaudtke,
C Zhang,
S Zhou,
L Zolin
University of Colorado, Boulder, Colorado 80309, USA.
We present measurements of J/ψ yields in d+Au collisions at sqrt[s_{NN}]=200 GeV recorded by the PHENIX experiment and compare them with yields in p+p collisions at the same energy per nucleon-nucleon collision. The measurements cover a large kinematic range in J/ψ rapidity (-2.2<y<2.4) with high statistical precision and are compared with two theoretical models: one with nuclear shadowing combined with final state breakup and one with coherent gluon saturation effects. In order to remove model dependent systematic uncertainties we also compare the data to a simple geometric model. The forward rapidity data are inconsistent with nuclear modifications that are linear or exponential in the density weighted longitudinal thickness, such as those from the final state breakup of the bound state.
Majed Abed,
Christopher Adlbrecht,
Jose Antonio Amado Señarís,
Jasmin Amighi,
Hendrik J Ankersmit,
Jose R de Berrazueta,
Elisabetta Bobbioni-Harsch,
Kathryn Boyle,
Christa Buechler,
Michele Buemi,
Valeria Cernaro,
Je-Ken Chang,
Chung-Hwan Chen,
Wen-Ping Cheng,
Alberto Cuocolo,
Robin P F Dullaart,
Pedram Ghafourifar,
Przemyslaw Guzik,
Michael M Hoffmann,
Jeroni Jurado,
Ville Kytö,
Florian Lang,
Michael Lichtenauer,
Zu-Yau Lin,
Yoshitaka Minami,
David Montero,
Farouk Mookadam,
Emanuele Nicolai,
Richard Pacher,
Reza Rahimian,
Mamoru Satoh,
Pekka Saukko,
Edgar Selzer,
Kou-Gi Shyu,
Juan Sztajzel,
Agnès Vinet,
Martin A Walter,
Michael Willmann,
Karl Winkler,
Andrzej Wykretowicz,
Mustafa Y Köker,
Juan Ybarra
Division of Angiology, Department of Physiology, University of Tuebingen, Tübingen, Germany Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria Department of Cardiology, Research Unit IFIMAV, Cantabria University, University Hospital Valdecilla, Santander, Spain Division of Angiology, Department of Internal Medicine II Department of Thoracic Surgery, Medical University Vienna Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration, Vienna, Austria Service of Therapeutic Education for Chronic Diseases, Geneva University Hospital, Geneva, Switzerland Dalton Cardiovascular Research Center, University of Missouri-Columbia, Columbia, MO, USA Department of Internal Medicine I, Regensburg University Hospital, Regensburg, Germany Division of Nephrology, Department of Internal Medicine, University of Messina, Messina, Italy Department of Orthopaedics, Kaohsiung Medical University Hospital Orthopaedic Research Center Faculty of Medicine, Departments of Orthopaedics and Sports Medicine, Graduate Institute of Medicine, College of Medicine Department of Orthopaedics, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung Division of Cardiology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan Department of Biomorphological and Functional Sciences University Federico II, Napoli, Italy Department of Endocrinology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands Tri-State Institute of Pharmaceutical Sciences, Huntington, WV, USA Division of Cardiology-Intensive Therapy, Department of Internal Medicine, University School of Medicine, Poznan, Poland Department of Clinical Chemistry, University Medical Center Freiburg, Freiburg, Germany IDIAP J Gol, Catalan Health Institute, Olot, Girona, Spain Department of Medicine, Turku University Hospital, Turku, Finland Cancer Center and Division of Hepatobiliary Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan Division of Cardiology, Department of Internal Medicine and Memorial Heart Center, Iwate Medical University School of Medicine EA4278 Physiology and Physiopathology of Cardiovascular Adaptations to Exercise, Faculty of Sciences, Avignon, France SDN Foundation, Institute of Diagnostic and Nuclear Development, Napoli, Italy Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Department of Forensic Medicine, University of Turku, Turku, Finland Department of Radiotherapy, Medical University Vienna, Vienna, Austria Cardiology Service, Geneva University Hospital, Geneva Institute of Nuclear Medicine, University Hospital, Bern, Switzerland Clinic for Internal Medicine and Infectious Diseases, University of Veterinary, Medicine Vienna, Vienna, Austria Laboratory, and Cappadocia Transplant Centre, Department of Internal Medicine, University of Erciyes, Kayseri, Turkey Centro MédicoTeknon, Barcelona, Spain.
Matern Child Health J. 2011 Sep 9;:
21904860
Robin L Toblin,
Ruth A Brenner,
Gitanjali S Taneja,
Maryann W Rossi,
Millicent Collins,
Angela D Mickalide,
Mary D Overpeck,
Yvette Clinton-Reid,
Jill A Dever,
Kerrie Boyle,
Ann C Trumble,
Peter C Scheidt
Military Psychiatry Branch, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD, 20910, USA, robin.l.toblin@us.army.mil.
The objective of this study is to determine prevention strategies for potentially serious injury events among children younger than 3 years of age based upon circumstances surrounding injury events. Surveillance was conducted on all injuries to District of Columbia (DC) residents less than 3 years old that resulted in an Emergency Department (ED) visit, hospitalization, or death for 1 year. Data were collected through abstraction of medical records and interviews with a subset of parents of injured children. Investigators coded injury-related events for the potential for death or disability. Potential prevention strategies were then determined for all injury events that had at least a moderate potential for death or disability and sufficient detail for coding (n = 425). Injury-related events included 10 deaths, 163 hospitalizations, and 2,868 ED visits (3,041 events in total). Of the hospitalizations, 88% were coded as moderate or high potential for disability or death, versus only 21% of the coded ED visits. For potentially serious events, environmental change strategies were identified for 47%, behavior change strategies for 77%, and policy change strategies for 24%. For 46% of the events more than one type of prevention strategy was identified. Only 8% had no identifiable prevention strategy. Prevention strategies varied by specific cause of injury. Potential prevention strategies were identifiable for nearly all potentially serious injury events, with multiple potential prevention strategies identified for a large fraction of the events. These findings support developing multifaceted prevention approaches informed by community-based injury surveillance.
The purpose of this policy brief is to provide policy makers, researchers, and stakeholders with information about the closure of rural independently owned pharmacies, including pharmacies that are the sole source of access to local pharmacy services, from 2003 through 2010. This period coincides with the implementation of two major policies related to payment for prescription medications:(1) Medicare prescription drug discount cards were introduced on January 1, 2004; and (2) the Medicare prescription drug benefit began on January 1, 2006. In this brief, we focus on rural pharmacy closure because of the potential threat such closures present to access to any local pharmacy services in a community. Those services include providing medications as needed (not waiting for mail order), overseeing administration of medications to nursing homes and hospitals, and patient consultation.
Nanoscale Res Lett. 2011 ;6 (1):294
21711786
Physics Department, University of Northern Iowa, Cedar Falls, IA 50614, USA. tim.kidd@uni.edu.
ABSTRACT: Two new methods for synthesizing nanostructured HfO2 have been developed. The first method entails exposing HfTe2 powders to air. This simple process resulted in the formation of nanometer scale crystallites of HfO2. The second method involved a two-step heating process by which macroscopic, freestanding nanosheets of HfO2 were formed as a byproduct during the synthesis of HfTe2. These highly two-dimensional sheets had side lengths measuring up to several millimeters and were stable enough to be manipulated with tweezers and other instruments. The thickness of the sheets ranged from a few to a few hundred nanometers. The thinnest sheets appeared transparent when viewed in a scanning electron microscope. It was found that the presence of Mn enhanced the formation of HfO2 by exposure to ambient conditions and was necessary for the formation of the large scale nanosheets. These results present new routes to create freestanding nanostructured hafnium dioxide.PACS: 81.07.-b, 61.46.Hk, 68.37.Hk.
Lorenza Ciani,
Kieran A Boyle,
Ellen Dickins,
Macarena Sahores,
Derek Anane,
Douglas M Lopes,
Alasdair J Gibb,
Patricia C Salinas
Department of Cell and Developmental Biology, University College London, London WC1E 6BT, United Kingdom.
The balance between excitatory and inhibitory synapses is crucial for normal brain function. Wnt proteins stimulate synapse formation by increasing synaptic assembly. However, it is unclear whether Wnt signaling differentially regulates the formation of excitatory and inhibitory synapses. Here, we demonstrate that Wnt7a preferentially stimulates excitatory synapse formation and function. In hippocampal neurons, Wnt7a increases the number of excitatory synapses, whereas inhibitory synapses are unaffected. Wnt7a or postsynaptic expression of Dishevelled-1 (Dvl1), a core Wnt signaling component, increases the frequency and amplitude of miniature excitatory postsynaptic currents (mEPSCs), but not miniature inhibitory postsynaptic currents (mIPSCs). Wnt7a increases the density and maturity of dendritic spines, whereas Wnt7a-Dvl1-deficient mice exhibit defects in spine morphogenesis and mossy fiber-CA3 synaptic transmission in the hippocampus. Using a postsynaptic reporter for Ca(2+)/Calmodulin-dependent protein kinase II (CaMKII) activity, we demonstrate that Wnt7a rapidly activates CaMKII in spines. Importantly, CaMKII inhibition abolishes the effects of Wnt7a on spine growth and excitatory synaptic strength. These data indicate that Wnt7a signaling is critical to regulate spine growth and synaptic strength through the local activation of CaMKII at dendritic spines. Therefore, aberrant Wnt7a signaling may contribute to neurological disorders in which excitatory signaling is disrupted.
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