| author name | recommending | commenting | favorite | papers | recom. | cited | |
|---|---|---|---|---|---|---|---|
| 0 | 0 | 0 | 569 | 0 | 10902 | [Update] | |
| 0 | 0 | 0 | 1 | 0 | 0 | [Update] | |
| 0 | 0 | 0 | 13 | 0 | 39 | [Update] | |
| 0 | 0 | 0 | 1 | 0 | 0 | [Update] | |
| 0 | 0 | 0 | 1 | 0 | 0 | [Update] | |
| 0 | 0 | 0 | 1 | 0 | 4 | [Update] | |
| 0 | 0 | 0 | 1 | 0 | 0 | [Update] | |
| 0 | 0 | 0 | 1 | 0 | 3 | [Update] | |
| 0 | 0 | 0 | 8 | 0 | 8 | [Update] | |
| 0 | 0 | 0 | 1 | 0 | 0 | [Update] | |
| 0 | 0 | 0 | 1 | 0 | 23 | [Update] | |
| 0 | 0 | 0 | 2 | 0 | 3 | [Update] | |
| 0 | 0 | 0 | 7 | 0 | 100 | [Update] | |
| 0 | 0 | 0 | 7 | 0 | 90 | [Update] | |
| 0 | 0 | 0 | 4 | 0 | 11 | [Update] | |
| 0 | 0 | 0 | 1 | 0 | 14 | [Update] | |
| 0 | 0 | 0 | 19 | 0 | 0 | [Update] | |
| 0 | 0 | 0 | 1 | 0 | 10 | [Update] | |
| 0 | 0 | 0 | 3 | 0 | 2 | [Update] | |
| 0 | 0 | 0 | 7 | 0 | 76 | [Update] | |
| 0 | 0 | 0 | 1 | 0 | 4 | [Update] |
Latest Paper:
S Chatrchyan,
V Khachatryan,
A M Sirunyan,
A Tumasyan,
W Adam,
T Bergauer,
M Dragicevic,
J Erö,
C Fabjan,
M Friedl,
R Frühwirth,
V M Ghete,
J Hammer,
M Hoch,
N Hörmann,
J Hrubec,
M Jeitler,
W Kiesenhofer,
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D Liko,
I Mikulec,
M Pernicka,
B Rahbaran,
C Rohringer,
H Rohringer,
R Schöfbeck,
J Strauss,
A Taurok,
F Teischinger,
P Wagner,
W Waltenberger,
G Walzel,
E Widl,
C-E Wulz,
V Mossolov,
N Shumeiko,
J Suarez Gonzalez,
S Bansal,
L Benucci,
T Cornelis,
E A De Wolf,
X Janssen,
S Luyckx,
T Maes,
L Mucibello,
S Ochesanu,
B Roland,
R Rougny,
M Selvaggi,
H Van Haevermaet,
P Van Mechelen,
N Van Remortel,
A Van Spilbeeck,
F Blekman,
S Blyweert,
J D'Hondt,
R Gonzalez Suarez,
A Kalogeropoulos,
M Maes,
A Olbrechts,
W Van Doninck,
P Van Mulders,
G P Van Onsem,
I Villella,
O Charaf,
B Clerbaux,
G De Lentdecker,
V Dero,
A P R Gay,
G H Hammad,
T Hreus,
A Léonard,
P E Marage,
L Thomas,
C Vander Velde,
P Vanlaer,
J Wickens,
V Adler,
K Beernaert,
A Cimmino,
S Costantini,
G Garcia,
M Grunewald,
B Klein,
J Lellouch,
A Marinov,
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A A Ocampo Rios,
D Ryckbosch,
N Strobbe,
F Thyssen,
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N Schul,
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E Daubie,
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A Santoro,
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R Trayanov,
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A Karadzhinova,
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L Litov,
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J G Bian,
G M Chen,
H S Chen,
C H Jiang,
D Liang,
S Liang,
X Meng,
J Tao,
J Wang,
X Wang,
Z Wang,
H Xiao,
M Xu,
J Zang,
Z Zhang,
C Asawatangtrakuldee,
Y Ban,
S Guo,
Y Guo,
W Li,
S Liu,
Y Mao,
S J Qian,
H Teng,
S Wang,
B Zhu,
W Zou,
A Cabrera,
B Gomez Moreno,
A F Osorio Oliveros,
J C Sanabria,
N Godinovic,
D Lelas,
R Plestina,
D Polic,
I Puljak,
Z Antunovic,
M Dzelalija,
M Kovac,
V Brigljevic,
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K Kadija,
J Luetic,
S Morovic,
A Attikis,
M Galanti,
J Mousa,
C Nicolaou,
F Ptochos,
P A Razis,
M Finger,
M Finger Jr,
Y Assran,
A Ellithi Kamel,
S Khalil,
M A Mahmoud,
A Radi,
A Hektor,
M Kadastik,
M Müntel,
M Raidal,
L Rebane,
A Tiko,
V Azzolini,
P Eerola,
G Fedi,
M Voutilainen,
S Czellar,
J Härkönen,
A Heikkinen,
V Karimäki,
R Kinnunen,
M J Kortelainen,
T Lampén,
K Lassila-Perini,
S Lehti,
T Lindén,
P Luukka,
T Mäenpää,
T Peltola,
E Tuominen,
J Tuominiemi,
E Tuovinen,
D Ungaro,
L Wendland,
K Banzuzi,
A Korpela,
T Tuuva,
D Sillou,
M Besancon,
S Choudhury,
M Dejardin,
D Denegri,
B Fabbro,
J L Faure,
F Ferri,
S Ganjour,
A Givernaud,
P Gras,
G Hamel de Monchenault,
P Jarry,
E Locci,
J Malcles,
L Millischer,
J Rander,
A Rosowsky,
I Shreyber,
M Titov,
S Baffioni,
F Beaudette,
L Benhabib,
L Bianchini,
M Bluj,
C Broutin,
P Busson,
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N Daci,
T Dahms,
L Dobrzynski,
S Elgammal,
R Granier de Cassagnac,
M Haguenauer,
P Miné,
C Mironov,
C Ochando,
P Paganini,
D Sabes,
R Salerno,
Y Sirois,
C Thiebaux,
C Veelken,
A Zabi,
J-L Agram,
J Andrea,
D Bloch,
D Bodin,
J-M Brom,
M Cardaci,
E C Chabert,
C Collard,
E Conte,
F Drouhin,
C Ferro,
J-C Fontaine,
D Gelé,
U Goerlach,
P Juillot,
M Karim,
A-C Le Bihan,
P Van Hove,
F Fassi,
D Mercier,
C Baty,
S Beauceron,
N Beaupere,
M Bedjidian,
O Bondu,
G Boudoul,
D Boumediene,
H Brun,
J Chasserat,
R Chierici,
D Contardo,
P Depasse,
H El Mamouni,
A Falkiewicz,
J Fay,
S Gascon,
M Gouzevitch,
B Ille,
T Kurca,
T Le Grand,
M Lethuillier,
L Mirabito,
S Perries,
V Sordini,
S Tosi,
Y Tschudi,
P Verdier,
S Viret,
D Lomidze,
G Anagnostou,
S Beranek,
M Edelhoff,
L Feld,
N Heracleous,
O Hindrichs,
R Jussen,
K Klein,
J Merz,
A Ostapchuk,
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H Weber,
B Wittmer,
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M Ata,
J Caudron,
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M Erdmann,
A Güth,
T Hebbeker,
C Heidemann,
K Hoepfner,
T Klimkovich,
D Klingebiel,
P Kreuzer,
D Lanske,
J Lingemann,
C Magass,
M Merschmeyer,
A Meyer,
M Olschewski,
P Papacz,
H Pieta,
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S A Schmitz,
L Sonnenschein,
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W Behrenhoff,
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I-A Melzer-Pellmann,
A B Meyer,
J Mnich,
A Mussgiller,
S Naumann-Emme,
J Olzem,
A Petrukhin,
D Pitzl,
A Raspereza,
P M Ribeiro Cipriano,
M Rosin,
J Salfeld-Nebgen,
R Schmidt,
T Schoerner-Sadenius,
N Sen,
A Spiridonov,
M Stein,
J Tomaszewska,
R Walsh,
C Wissing,
C Autermann,
V Blobel,
S Bobrovskyi,
J Draeger,
H Enderle,
J Erfle,
U Gebbert,
M Görner,
T Hermanns,
R S Höing,
K Kaschube,
G Kaussen,
H Kirschenmann,
R Klanner,
J Lange,
B Mura,
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N Pietsch,
C Sander,
H Schettler,
P Schleper,
E Schlieckau,
A Schmidt,
M Schröder,
T Schum,
H Stadie,
G Steinbrück,
J Thomsen,
C Barth,
J Berger,
T Chwalek,
W De Boer,
A Dierlamm,
G Dirkes,
M Feindt,
J Gruschke,
M Guthoff,
C Hackstein,
F Hartmann,
M Heinrich,
H Held,
K H Hoffmann,
S Honc,
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F M Stober,
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L Brigliadori,
P Capiluppi,
A Castro,
F R Cavallo,
M Cuffiani,
G M Dallavalle,
F Fabbri,
A Fanfani,
D Fasanella,
P Giacomelli,
C Grandi,
S Marcellini,
G Masetti,
M Meneghelli,
A Montanari,
F L Navarria,
F Odorici,
A Perrotta,
F Primavera,
A M Rossi,
T Rovelli,
G Siroli,
R Travaglini,
S Albergo,
G Cappello,
M Chiorboli,
S Costa,
R Potenza,
A Tricomi,
C Tuve,
G Barbagli,
V Ciulli,
C Civinini,
R D'Alessandro,
E Focardi,
S Frosali,
E Gallo,
S Gonzi,
M Meschini,
S Paoletti,
G Sguazzoni,
A Tropiano,
L Benussi,
S Bianco,
S Colafranceschi,
D Piccolo,
P Fabbricatore,
R Musenich,
A Benaglia,
F De Guio,
L Di Matteo,
S Fiorendi,
S Gennai,
A Ghezzi,
S Malvezzi,
R A Manzoni,
A Martelli,
A Massironi,
D Menasce,
L Moroni,
M Paganoni,
D Pedrini,
S Ragazzi,
N Redaelli,
S Sala,
T Tabarelli de Fatis,
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C A Carrillo Montoya,
N Cavallo,
A De Cosa,
O Dogangun,
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L Lista,
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P Paolucci,
P Azzi,
N Bacchetta,
P Bellan,
D Bisello,
A Branca,
R Carlin,
P Checchia,
T Dorigo,
U Dosselli,
F Fanzago,
F Gasparini,
U Gasparini,
A Gozzelino,
K Kanishchev,
S Lacaprara,
I Lazzizzera,
M Loreti,
M Margoni,
M Mazzucato,
A T Meneguzzo,
M Nespolo,
L Perrozzi,
N Pozzobon,
P Ronchese,
F Simonetto,
E Torassa,
M Tosi,
S Vanini,
P Zotto,
G Zumerle,
U Berzano,
M Gabusi,
S P Ratti,
C Riccardi,
P Torre,
P Vitulo,
M Biasini,
G M Bilei,
B Caponeri,
L Fanò,
P Lariccia,
A Lucaroni,
G Mantovani,
M Menichelli,
A Nappi,
F Romeo,
A Santocchia,
S Taroni,
M Valdata,
P Azzurri,
G Bagliesi,
T Boccali,
G Broccolo,
R Castaldi,
R T D'Agnolo,
R Dell'orso,
F Fiori,
L Foà,
A Giassi,
A Kraan,
F Ligabue,
T Lomtadze,
L Martini,
A Messineo,
F Palla,
F Palmonari,
A Rizzi,
A T Serban,
P Spagnolo,
R Tenchini,
G Tonelli,
A Venturi,
P G Verdini,
L Barone,
F Cavallari,
D Del Re,
M Diemoz,
C Fanelli,
M Grassi,
E Longo,
P Meridiani,
F Micheli,
S Nourbakhsh,
G Organtini,
F Pandolfi,
R Paramatti,
S Rahatlou,
M Sigamani,
L Soffi,
N Amapane,
R Arcidiacono,
S Argiro,
M Arneodo,
C Biino,
C Botta,
N Cartiglia,
R Castello,
M Costa,
N Demaria,
A Graziano,
C Mariotti,
S Maselli,
E Migliore,
V Monaco,
M Musich,
M M Obertino,
N Pastrone,
M Pelliccioni,
A Potenza,
A Romero,
M Ruspa,
R Sacchi,
V Sola,
A Solano,
A Staiano,
A Vilela Pereira,
S Belforte,
F Cossutti,
G Della Ricca,
B Gobbo,
M Marone,
D Montanino,
A Penzo,
S G Heo,
S K Nam,
S Chang,
J Chung,
D H Kim,
G N Kim,
J E Kim,
D J Kong,
H Park,
S R Ro,
D C Son,
J Y Kim,
Zero J Kim,
S Song,
H Y Jo,
S Choi,
D Gyun,
B Hong,
M Jo,
H Kim,
T J Kim,
K S Lee,
D H Moon,
S K Park,
E Seo,
K S Sim,
M Choi,
S Kang,
J H Kim,
C Park,
I C Park,
S Park,
G Ryu,
Y Cho,
Y Choi,
Y K Choi,
J Goh,
M S Kim,
B Lee,
J Lee,
S Lee,
H Seo,
I Yu,
M J Bilinskas,
I Grigelionis,
M Janulis,
H Castilla-Valdez,
E De La Cruz-Burelo,
I Heredia-de La Cruz,
R Lopez-Fernandez,
R Magaña Villalba,
J Martínez-Ortega,
A Sánchez-Hernández,
L M Villasenor-Cendejas,
S Carrillo Moreno,
F Vazquez Valencia,
H A Salazar Ibarguen,
E Casimiro Linares,
A Morelos Pineda,
M A Reyes-Santos,
D Krofcheck,
A J Bell,
P H Butler,
R Doesburg,
S Reucroft,
H Silverwood,
M Ahmad,
M I Asghar,
H R Hoorani,
S Khalid,
W A Khan,
T Khurshid,
S Qazi,
M A Shah,
M Shoaib,
G Brona,
M Cwiok,
W Dominik,
K Doroba,
A Kalinowski,
M Konecki,
J Krolikowski,
H Bialkowska,
B Boimska,
T Frueboes,
R Gokieli,
M Górski,
M Kazana,
K Nawrocki,
K Romanowska-Rybinska,
M Szleper,
G Wrochna,
P Zalewski,
N Almeida,
P Bargassa,
A David,
P Faccioli,
P G Ferreira Parracho,
M Gallinaro,
P Musella,
A Nayak,
J Pela,
P Q Ribeiro,
J Seixas,
J Varela,
P Vischia,
I Belotelov,
I Golutvin,
N Gorbounov,
I Gramenitski,
A Kamenev,
V Karjavin,
V Konoplyanikov,
V Korenkov,
G Kozlov,
A Lanev,
P Moisenz,
V Palichik,
V Perelygin,
M Savina,
S Shmatov,
S Vasil'ev,
A Zarubin,
S Evstyukhin,
V Golovtsov,
Y Ivanov,
V Kim,
P Levchenko,
V Murzin,
V Oreshkin,
I Smirnov,
V Sulimov,
L Uvarov,
S Vavilov,
A Vorobyev,
An Vorobyev,
Yu Andreev,
A Dermenev,
S Gninenko,
N Golubev,
M Kirsanov,
N Krasnikov,
V Matveev,
A Pashenkov,
A Toropin,
S Troitsky,
V Epshteyn,
M Erofeeva,
V Gavrilov,
M Kossov,
A Krokhotin,
N Lychkovskaya,
V Popov,
G Safronov,
S Semenov,
V Stolin,
E Vlasov,
A Zhokin,
A Belyaev,
E Boos,
M Dubinin,
L Dudko,
A Ershov,
A Gribushin,
O Kodolova,
I Lokhtin,
A Markina,
S Obraztsov,
M Perfilov,
S Petrushanko,
L Sarycheva,
V Savrin,
A Snigirev,
V Andreev,
M Azarkin,
I Dremin,
M Kirakosyan,
A Leonidov,
G Mesyats,
S V Rusakov,
A Vinogradov,
I Azhgirey,
I Bayshev,
S Bitioukov,
V Grishin,
V Kachanov,
D Konstantinov,
A Korablev,
V Krychkine,
V Petrov,
R Ryutin,
A Sobol,
L Tourtchanovitch,
S Troshin,
N Tyurin,
A Uzunian,
A Volkov,
P Adzic,
M Djordjevic,
M Ekmedzic,
D Krpic,
J Milosevic,
M Aguilar-Benitez,
J Alcaraz Maestre,
P Arce,
C Battilana,
E Calvo,
M Cerrada,
M Chamizo Llatas,
N Colino,
B De La Cruz,
A Delgado Peris,
C Diez Pardos,
D Domínguez Vázquez,
C Fernandez Bedoya,
J P Fernández Ramos,
A Ferrando,
J Flix,
M C Fouz,
P Garcia-Abia,
O Gonzalez Lopez,
S Goy Lopez,
J M Hernandez,
M I Josa,
G Merino,
J Puerta Pelayo,
I Redondo,
L Romero,
J Santaolalla,
M S Soares,
C Willmott,
C Albajar,
G Codispoti,
J F de Trocóniz,
J Cuevas,
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Yerevan Physics Institute, Yerevan, Armenia.
A search for a Higgs boson in the four-lepton decay channel H→ZZ, with each Z boson decaying to an electron or muon pair, is reported. The search covers Higgs boson mass hypotheses in the range of 110<m_{H}<600 GeV. The analysis uses data corresponding to an integrated luminosity of 4.7 fb^{-1} recorded by the CMS detector in pp collisions at sqrt[s]=7 TeV from the LHC. Seventy-two events are observed with four-lepton invariant mass m_{4ℓ}>100 GeV (with 13 below 160 GeV), while 67.1±6.0 (9.5±1.3) events are expected from background. The four-lepton mass distribution is consistent with the expectation of standard model background production of ZZ pairs. Upper limits at 95% confidence level exclude the standard model Higgs boson in the ranges of 134-158 GeV, 180-305 GeV, and 340-465 GeV. Small excesses of events are observed around masses of 119, 126, and 320 GeV, making the observed limits weaker than expected in the absence of a signal.
S Chatrchyan,
V Khachatryan,
A M Sirunyan,
A Tumasyan,
W Adam,
T Bergauer,
M Dragicevic,
J Erö,
C Fabjan,
M Friedl,
R Frühwirth,
V M Ghete,
J Hammer,
M Hoch,
N Hörmann,
J Hrubec,
M Jeitler,
W Kiesenhofer,
A Knapitsch,
M Krammer,
D Liko,
I Mikulec,
M Pernicka,
B Rahbaran,
H Rohringer,
R Schöfbeck,
J Strauss,
A Taurok,
F Teischinger,
C Trauner,
P Wagner,
W Waltenberger,
G Walzel,
E Widl,
C-E Wulz,
V Mossolov,
N Shumeiko,
J Suarez Gonzalez,
S Bansal,
L Benucci,
E A De Wolf,
X Janssen,
S Luyckx,
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W H Smith,
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M Weinberg
Yerevan Physics Institute, Yerevan, Armenia.
A search for signatures of extra spatial dimensions in the diphoton invariant-mass spectrum has been performed with the CMS detector at the LHC. No excess of events above the standard model expectation is observed using a data sample collected in proton-proton collisions at sqrt[s]=7 TeV corresponding to an integrated luminosity of 2.2 fb^{-1}. In the context of the large-extra-dimensions model, lower limits are set on the effective Planck scale in the range of 2.3-3.8 TeV at the 95% confidence level. These limits are the most restrictive bounds on virtual-graviton exchange to date. The most restrictive lower limits to date are also set on the mass of the first graviton excitation in the Randall-Sundrum model in the range of 0.86-1.84 TeV, for values of the associated coupling parameter between 0.01 and 0.10.
a Farm Safety 4 Just Kids.
Ulster Med J. 2011 Jan ;80 (1):33-41
22347739
Peripheral arterial disease (PAD) now affects approximately 20% of adults older than 55 years to an estimated total of 27 million people in the Western World. The aim of this paper is to describe the medical management of PAD for the non-vascular specialist, particularly general practitioners, where PAD has now been included in the Northern Ireland Department of Health's Primary Care Service Framework (Directed Enhanced Service).
aDepartment of Gastroenterology, University Hospital Llandough, Penarth bUniversity Hospital Llandough cUniversity Hospital of Wales, Cardiff dBristol Royal Infirmary, Bristol, UK.
OBJECTIVE: To determine whether there is a continued increase in the incidence of coeliac disease (CD) in the population of Cardiff and the Vale of Glamorgan between 1996 and 2005 compared with previous data for 1981-1995, and to describe the presenting features during this time. DESIGN: Retrospective case-finding study using pathology, dietetic and clinical records held in hospitals and general practice within Cardiff and the Vale of Glamorgan. All local consultants including those at private hospitals were contacted. Incidence rates were calculated using the Welsh Assembly Government's mid-year estimates. RESULTS: In total, 347 newly diagnosed cases of CD (42 children, 305 adults) were detected. Compared with previous published data, incidence rates in adults per 100 000 have increased from 3.08 at the end of 1995 to 11.13 in 2005. In children, the disease incidence has trebled to 6.89 per 100 000. There have been some changes in presenting symptoms, with a marked preponderance of abdominal pain and bloating in women (P<0.05). There has been a 14-fold increase in the numbers of patients undergoing coeliac serology testing from 1996 to 2005, associated with an increased absolute number of new cases. However, the proportion of new cases diagnosed compared with numbers of serological tests performed decreased from 5.8 to 1.1%. CONCLUSION: The incidence of CD in children and adults has markedly increased. One of the most striking features of our data in adult CD is the increasing frequency of abdominal pain and bloating in the female cohort. Incorporation of antibody testing into clinical guidelines is likely to result in a wider spectrum of individuals with nonspecific gastrointestinal symptoms being investigated and diagnosed with CD in the future.
BJOG. 2012 Mar ;119 (4):510
22324929
P von Dadelszen,
Ki Lim,
S Dwinnell,
LA Magee,
Bc Carleton,
A Gruslin,
B Lee,
Rm Liston,
Sp Miller,
D Rurak,
Rl Sherlock,
Ma Skoll,
Mm Wareing,
Pn Baker
Department of Obstetrics and Gynaecology School of Public and Population Health Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada Department of Obstetrics and Gynaecology, University of Calgary, Calgary, AB, Canada Department of Medicine Department of Paediatrics, University of British Columbia, Vancouver, BC, Canada Department of Obstetrics and Gynaecology, University of Ottawa, Ottawa, ON, Canada Maternal and Fetal Health Research Group, University of Manchester, Manchester, UK Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
Department of Surgery, Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea.
Many studies have explored the participation of cytokines and their genes in renal allograft rejection by using biopsy tissues. To screen for rejection, a biopsy is too invasive to perform without a clinical clue. Therefore, we studied the expression of cytokines that contribute to the early phase of allograft rejection by analyzing mRNA transcripts in sequential blood samples of peripheral blood mononuclear cells (PBMCs) 120 of 6 among patients transplanted before diagnosis of rejection. for comparison with 6 control recipients. The relative expression amount of cytokine genes encoding interleukin (IL) 2, IL-4, IL-10, IL-15, and interferon-γ were assessed using real-time reverse-transcription polymerase chain reactions. IL-2, IL-4, and IL-15 mRNA expressions in clinically stable prerejection phase of the rejection group were significantly higher than those of the control group. In the prerejection samples, the expression of mRNA encoding IL-10 negatively correlated with the expressions of IL-2, IL-4, and IL-15 mRNAs, which were not different from the positive correlations in the postoperative samples from the control group. The expression patterns of IL-2, IL-4, IL-10, and IL-15 genes in PBMCs after transplantation may help to identify acute rejection episodes before clinical deterioration to monitor the efficacy of immunosuppressive treatment.
Department of Laboratory Medicine, Hallym University College of Medicine, Seoul, Korea.
OBJECTIVE HLA alloimmunization is caused by various sensitization events, such as transfusion, pregnancy, or organ transplantation. However, the effects of a particular sensitization event on HLA alloimmunization have not been well studied in parallel using an identical test method. We evaluated how different sensitization events affect the panel-reactive antibody (PRA) status in solid organ transplantation candidates. METHODS PRA identification tests were performed on 674 patients (354 males and 320 females) using Luminex assay kits (LIFECODES, Gen-Probe, Stamford, CT, United States). PRA-positive rates (HLA-A, B, or DR antibodies of median fluorescence intensity [MFI] values of ≥1000) and antibody strengths in PRA-positive cases were analyzed according to the different sensitization events and gender. RESULTS PRA (class I and/or II)-positive rates were significantly higher in patients with transfusion (33.0%; P =.001), pregnancy (71.4%; P <.001), or transplantation events (76.9%; P <.001) than in controls without any identifiable sensitization events (5.6%). Transplantation had the strongest immunization effect, especially for class II HLA antigens. Female compared with male patients (60.3% vs 34.2%; P <.001) and retransplantation compared with first transplantation candidates of kidney transplantation (80.2% vs 41.1%; P <.001) showed a significantly higher PRA-positive rate. Retransplantation candidates (MFI 14,164) showed significantly stronger antibody strength than first transplantation candidates (MFI 5456) and those with single sensitization events of transfusion (MFI 4185) or pregnancy (MFI 5548; P <.001 for each). CONCLUSION Solid organ transplantation appears to have the strongest HLA alloimmunization effect followed by pregnancy and transfusion, especially for class II HLA antigens.
Curr Biol. 2012 Feb 7;22 (3):220-4
22264612
Graduate Center for Vision Research, State University of New York, College of Optometry, New York, NY 10036, USA. qz@sunyopt.edu
After fixating on a colored pattern, observers see a similar pattern in complementary colors when the stimulus is removed [1-6]. Afterimages were important in disproving the theory that visual rays emanate from the eye, in demonstrating interocular interactions, and in revealing the independence of binocular vision from eye movements. Afterimages also prove invaluable in exploring selective attention, filling in, and consciousness. Proposed physiological mechanisms for color afterimages range from bleaching of cone photopigments to cortical adaptation [4-9], but direct neural measurements have not been reported. We introduce a time-varying method for evoking afterimages, which provides precise measurements of adaptation and a direct link between visual percepts and neural responses [10]. We then use in vivo electrophysiological recordings to show that all three classes of primate retinal ganglion cells exhibit subtractive adaptation to prolonged stimuli, with much slower time constants than those expected of photoreceptors. At the cessation of the stimulus, ganglion cells generate rebound responses that can provide afterimage signals for later neurons. Our results indicate that afterimage signals are generated in the retina but may be modified like other retinal signals by cortical processes, so that evidence presented for cortical generation of color afterimages is explainable by spatiotemporal factors that modify all signals.
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