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Latest Paper:
Maria Margarita Gonzalez,
Flávio Rocha Brito Marques,
Caio Brito Vianna,
Carlos Alberto Eid,
Gilson Soares Feitosa-Filho,
Sergio Timerman
Instituto do Coração, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil. maria.gonzalez@incor.usp.br
Survival after out-of-hospital cardiopulmonary arrest is estimated at less than 5%. We report a case of ventricular fibrillation during sports activity. Cardiopulmonary resuscitation was initiated early by a layperson, and defibrillation was successfully performed within less than three minutes, with an automated external defibrillator. The public access to defibrillation programs has increased the survival after out-of-hospital ventricular fibrillation. We should encourage the training of laypeople in relation to the use of automated external defibrillators and the Basic Life Support program by stimulating their implementation in places where large numbers of people gather or where people are at a high risk of sudden death, as is the case of sports centers.
Heart Institute (InCor), University of Sao Paulo Medical School, Avenue Doutor Eneas Carvalho Aguiar 44, 05403.900, Sao Paulo, SP, Brazil.
Keywords:
Maria M Gonzalez,
Robert A Berg,
Vinay M Nadkarni,
Caio B Vianna,
Karl B Kern,
Sergio Timerman,
Jose A Ramires
Heart Institute.
BACKGROUND:-The effect of prearrest left ventricular ejection fraction (LVEF) on outcome after cardiac arrest is unknown. Methods and Results-During a 26-month period, Utstein-style data were prospectively collected on 800 consecutive inpatient adult index cardiac arrests in an observational, single-center study at a tertiary cardiac care hospital. Prearrest echocardiograms were performed on 613 patients (77%) at 11+/-14 days before the cardiac arrest. Outcomes among patients with normal or nearly normal prearrest LVEF (>/=45%) were compared with those of patients with moderate or severe dysfunction (LVEF <45%) by chi(2) and logistic regression analyses. Survival to discharge was 19% in patients with normal or nearly normal LVEF compared with 8% in those with moderate or severe dysfunction (adjusted odds ratio, 4.8; 95% confidence interval, 2.3 to 9.9; P<0.001) but did not differ with regard to sustained return of spontaneous circulation (59% versus 56%; P=0.468) or 24-hour survival (39% versus 36%; P=0.550). Postarrest echocardiograms were performed on 84 patients within 72 hours after the index cardiac arrest; the LVEF decreased 25% in those with normal or nearly normal prearrest LVEF (60+/-9% to 45+/-14%; P<0.001) and decreased 26% in those with moderate or severe dysfunction (31+/-7% to 23+/-6%, P<0.001). For all patients, prearrest beta-blocker treatment was associated with higher survival to discharge (33% versus 8%; adjusted odds ratio, 3.9; 95% confidence interval, 1.8 to 8.2; P<0.001). Conclusions-Moderate and severe prearrest left ventricular systolic dysfunction was associated with substantially lower rates of survival to hospital discharge compared with normal or nearly normal function.
Raúl J Gazmuri,
Vinay M Nadkarni,
Jerry P Nolan,
Hans-Richard Arntz,
John E Billi,
Leo Bossaert,
Charles D Deakin,
Judith Finn,
William W Hammill,
Anthony J Handley,
Mary Fran Hazinski,
Robert W Hickey,
Ian Jacobs,
Edward C Jauch,
Walter G J Kloeck,
Mark H Mattes,
William H Montgomery,
Peter Morley,
Laurie J Morrison,
Graham Nichol,
Robert E O'Connor,
Jeffrey Perlman,
Sam Richmond,
Michael Sayre,
Michael Shuster,
Sergio Timerman,
Max Harry Weil,
Myron L Weisfeldt,
Arno Zaritsky,
David A Zideman
Keywords:
Raúl J Gazmuri,
Jerry P Nolan,
Vinay M Nadkarni,
Hans-Richard Arntz,
John E Billi,
Leo Bossaert,
Charles D Deakin,
Judith Finn,
William W Hammill,
Anthony J Handley,
Mary Fran Hazinski,
Robert W Hickey,
Ian Jacobs,
Edward C Jauch,
Walter G J Kloeck,
Mark H Mattes,
William H Montgomery,
Peter Morley,
Laurie J Morrison,
Graham Nichol,
Robert E O'Connor,
Jeffrey Perlman,
Sam Richmond,
Michael Sayre,
Michael Shuster,
Sergio Timerman,
Max Harry Weil,
Myron L Weisfeldt,
Arno Zaritsky,
David A Zideman
Keywords:
Sergio Timerman,
Maria Margarita Castro Gonzalez,
Evandro Tinoco Mesquita,
Flavio Rocha Brito Marques,
José Antônio Franchini Ramires,
Ana Paula Quilici,
Ari Timerman
Comitê Científico da Fundação Interamericana do Coração, São Paulo, SP, Brazil. timerman@cardiol.br
Keywords:
Miguel Antonio Moretti,
Luiz Antonio Machado Cesar,
Amit Nusbacher,
Karl B Kern,
Sergio Timerman,
José Antonio Franchini Ramires
Heart Institute (INCOR) at the University of Sao Paulo, Sao Paulo, Brazil.
CONTEXT: Advanced cardiac life support (ACLS) training was introduced to bring order and a systematic approach to the treatment of cardiac arrest by professional responders. In spite of the wide dissemination of ACLS training, it has been difficult to demonstrate improved outcome following such training. OBJECTIVE: To determine the value of formal ACLS training in improving survival from in-hospital cardiac arrest. DESIGN, SETTING, AND PARTICIPANTS: A multi-center, prospective cohort study examined patient outcomes after resuscitation efforts by in-hospital rescue teams with and without ACLS-trained personnel. A total of 156 patients, experiencing 172 in-hospital cardiopulmonary arrest events over a 38-month period (January 1998 to March 2001) were studied. MAIN OUTCOME MEASURES: Primary endpoints included return of spontaneous circulation (ROSC), survival to hospital discharge, 30-day survival, and 1-year survival. RESULTS: The immediate success of resuscitation efforts for all patients was 39.7%(62/156). There was a significant increase in ROSC with ACLS-trained personnel (49/113; 43.4%) versus no ALCS-trained personnel (16/59; 27.1%; p=0.04). Likewise, patients treated by ACLS-trained personnel had increased survival to hospital discharge (26/82; 31.7% versus 7/34; 20.6%; p=0.23), significantly better 30-day survival (22/82; 26.8% versus 2/34; 5.9%; p<0.02), and significantly improved 1-year survival (18/82; 21.9% versus 0/34; 0%; p<0.002). CONCLUSION: The presence of at least one ACLS-trained team member at in-hospital resuscitation efforts increases both short and long-term survival following cardiac arrest.
Vitor S Kawabata,
Caio B Vianna,
Miguel A Moretti,
Maria M Gonzalez,
João F Ferreira,
Sergio Timerman,
Luiz A Cesar
Heart Institute (INCOR-HCFMUSP), University of São Paulo Medical School, Av. Doutor Enéas Carvalho Aguiar 44, 05403.000 São Paulo, Brazil.
AIMS: With transthoracic cardioversion of atrial fibrillation (AF), biphasic are more effective than monophasic waveforms. We sought to determine the ideal energy levels for biphasic waveforms. Methods We compared biphasic truncated exponential waveforms with monophasic damped sine waveform defibrillators, in a prospective, single-centre, randomized (1:1 ratio) study. The study included 154 patients receiving concomitant amiodarone; 77 received serial biphasic (50, 100, 150, up to 175 J) and 77 monophasic shocks (100, 200, 300, up to 360 J), as necessary. Results First-shock efficacy was similar in the two groups (57 vs. 55%, P = 0.871, respectively), as were serial-shocks (90 vs. 92%, P = 0.780). Both groups received equal numbers of shocks (1.8 +/- 1.1 vs. 1.7 +/- 1.0, P = 0.921). In both groups, serum creatine kinase levels showed a small but significant increase. The increase was, however, higher in the monophasic group. CONCLUSION: In patients with concomitant amiodarone therapy, biphasic truncated exponential shocks, using half the energy, were as effective as monophasic damped sine shocks. The biphasic scheme was not more efficacious for cardioverting AF. In our population, a first shock of at least 100 J seemed advisable with either waveform. If necessary, escalating shocks must be performed, but ideal levels of increase per shock are still uncertain for biphasic waveforms.
Heart Institute (InCor), University of São Paulo Medical School, Brazil.
Myocardial bridging is a common and usually benign inborn coronary anomaly. We report on a 51-year-old man who presented with recent angina on minimum physical effort. Cineangiography showed myocardial bridging of the mid-left anterior descending artery (LAD), and intracoronary ultrasonography excluded atherosclerotic disease. Gated single-photon emission computed tomography (SPECT), with exercise stress, showed an extensive anterior perfusion defect, and remarkable ST-segment elevation (up to 10 mm) in recovery. Vasospasm of the LAD was the main hypothesis. Additional oral drugs did not bring about improvement, as indicated on a new SPECT; disabling angina persisted. Surgical revascularization of the LAD by left internal mammary artery graft was performed. Two years later, SPECT and exercise tests returned to normal. The patient remains asymptomatic.
Laboratory of Training and Simulation in Cardiovascular Emergencies, Heart Institute (InCor), University of São Paulo Medical School, Brazil.
Emergency medical services in Brazil have been created to offer first aid, primary medical treatment, basic life support, stabilization and rapid transfer to the closest appropriate hospital and advanced life support. Pre-hospital emergency care in Brazil is divided into permanent and mobile services. Permanent care is provided by the pre-hospital network (basic health units, family health program, specialized clinics, diagnosis and therapy services, non-hospital emergency care units). The mobile medical services include: mobile emergency care service, fire department and private services. Emergency hospital care units (emergency departments) are classified into general and reference units. Details of these services are described.
