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| 0 | 0 | 0 | 583 | 0 | 5634 | [Update] | |
| 0 | 0 | 0 | 4 | 0 | 58 | [Update] | |
| 0 | 0 | 0 | 83 | 0 | 1467 | [Update] | |
| 0 | 0 | 0 | 11 | 0 | 72 | [Update] | |
| 0 | 0 | 0 | 1 | 0 | 36 | [Update] | |
| 0 | 0 | 0 | 13 | 0 | 38 | [Update] | |
| 0 | 0 | 0 | 50 | 0 | 335 | [Update] | |
| 0 | 0 | 0 | 3 | 0 | 2 | [Update] | |
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| 0 | 0 | 0 | 1 | 0 | 4 | [Update] | |
| 0 | 0 | 0 | 4 | 0 | 1 | [Update] | |
| 0 | 0 | 0 | 4 | 0 | 0 | [Update] | |
| 0 | 0 | 0 | 2 | 0 | 7 | [Update] | |
| 0 | 0 | 0 | 73 | 0 | 1023 | [Update] | |
| 0 | 0 | 0 | 2 | 0 | 17 | [Update] | |
| 0 | 0 | 0 | 4 | 0 | 0 | [Update] | |
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| 0 | 0 | 0 | 4 | 0 | 47 | [Update] | |
| 0 | 0 | 0 | 1 | 0 | 1 | [Update] | |
| 0 | 0 | 0 | 14 | 0 | 0 | [Update] | |
| 0 | 0 | 0 | 1 | 0 | 0 | [Update] |
Latest Paper:
Laura Pascual,
Agata K Jakubowska,
Jose M Blanca,
Joaquin Cañizares,
Juan Ferré,
Gernot Gloeckner,
Heiko Vogel,
Salvador Herrero
Instituto de Conservación y Mejora de la Agrodiversidad Valenciana (COMAV), Universidad Politécnica de Valencia, Camino de Vera s/n, Valencia, Spain.
We have obtained and characterized the transcriptome of Spodoptera exigua larvae with special emphasis on pathogen-induced genes. In order to obtain a highly representative transcriptome, we have pooled RNA from diverse insect colonies, conditions and tissues. Sequenced cDNA included samples from 3 geographically different colonies. Enrichment of RNA from pathogen-related genes was accomplished by exposing larvae to different pathogenic and non-pathogenic microbial agents such as the bacteria Bacillus thuringiensis, Micrococcus luteus, and Escherichia coli, the yeast Saccharomyces cerevisiae, and the S. exigua nucleopolyhedrovirus (SeMNPV). In addition, to avoid the loss of tissue-specific genes we included cDNA from the midgut, fat body, hemocytes and integument derived from pathogen exposed insects. RNA obtained from the different types of samples was pooled, normalized and sequenced. Analysis of the sequences obtained using the Roche 454 FLX and Sanger methods has allowed the generation of the largest public set of ESTs from S. exigua, including a large group of immune genes, and the identification of an important number of SSR (simple sequence repeats) and SNVs (single nucleotide variants: SNPs and INDELs) with potential use as genetic markers. Moreover, data mining has allowed the discovery of novel RNA viruses with potential influence in the insect population dynamics and the larval interactions with the microbial pesticides that are currently in used for the biological control of this pest.
S Chatrchyan,
V Khachatryan,
A M Sirunyan,
A Tumasyan,
W Adam,
T Bergauer,
M Dragicevic,
J Erö,
C Fabjan,
M Friedl,
R Frühwirth,
V M Ghete,
J Hammer,
M Hoch,
N Hörmann,
J Hrubec,
M Jeitler,
W Kiesenhofer,
M Krammer,
D Liko,
I Mikulec,
M Pernicka,
B Rahbaran,
C Rohringer,
H Rohringer,
R Schöfbeck,
J Strauss,
A Taurok,
F Teischinger,
P Wagner,
W Waltenberger,
G Walzel,
E Widl,
C-E Wulz,
V Mossolov,
N Shumeiko,
J Suarez Gonzalez,
S Bansal,
L Benucci,
T Cornelis,
E A De Wolf,
X Janssen,
S Luyckx,
T Maes,
L Mucibello,
S Ochesanu,
B Roland,
R Rougny,
M Selvaggi,
H Van Haevermaet,
P Van Mechelen,
N Van Remortel,
A Van Spilbeeck,
F Blekman,
S Blyweert,
J D'Hondt,
R Gonzalez Suarez,
A Kalogeropoulos,
M Maes,
A Olbrechts,
W Van Doninck,
P Van Mulders,
G P Van Onsem,
I Villella,
O Charaf,
B Clerbaux,
G De Lentdecker,
V Dero,
A P R Gay,
G H Hammad,
T Hreus,
A Léonard,
P E Marage,
L Thomas,
C Vander Velde,
P Vanlaer,
J Wickens,
V Adler,
K Beernaert,
A Cimmino,
S Costantini,
G Garcia,
M Grunewald,
B Klein,
J Lellouch,
A Marinov,
J McCartin,
A A Ocampo Rios,
D Ryckbosch,
N Strobbe,
F Thyssen,
M Tytgat,
L Vanelderen,
P Verwilligen,
S Walsh,
E Yazgan,
N Zaganidis,
S Basegmez,
G Bruno,
L Ceard,
J De Favereau De Jeneret,
C Delaere,
T du Pree,
D Favart,
L Forthomme,
A Giammanco,
G Grégoire,
J Hollar,
V Lemaitre,
J Liao,
O Militaru,
C Nuttens,
D Pagano,
A Pin,
K Piotrzkowski,
N Schul,
N Beliy,
T Caebergs,
E Daubie,
G A Alves,
M Correa Martins Junior,
D De Jesus Damiao,
T Martins,
M E Pol,
M H G Souza,
W L Aldá Júnior,
W Carvalho,
A Custódio,
E M Da Costa,
C De Oliveira Martins,
S Fonseca De Souza,
D Matos Figueiredo,
L Mundim,
H Nogima,
V Oguri,
W L Prado Da Silva,
A Santoro,
S M Silva Do Amaral,
L Soares Jorge,
A Sznajder,
T S Anjos,
C A Bernardes,
F A Dias,
T R Fernandez Perez Tomei,
E M Gregores,
C Lagana,
F Marinho,
P G Mercadante,
S F Novaes,
Sandra S Padula,
V Genchev,
P Iaydjiev,
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M Rodozov,
S Stoykova,
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R Trayanov,
M Vutova,
A Dimitrov,
R Hadjiiska,
A Karadzhinova,
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J Tao,
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H Xiao,
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C Asawatangtrakuldee,
Y Ban,
S Guo,
Y Guo,
W Li,
S Liu,
Y Mao,
S J Qian,
H Teng,
S Wang,
B Zhu,
W Zou,
A Cabrera,
B Gomez Moreno,
A F Osorio Oliveros,
J C Sanabria,
N Godinovic,
D Lelas,
R Plestina,
D Polic,
I Puljak,
Z Antunovic,
M Dzelalija,
M Kovac,
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K Kadija,
J Luetic,
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A Attikis,
M Galanti,
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C Nicolaou,
F Ptochos,
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M Finger,
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A Ellithi Kamel,
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M A Mahmoud,
A Radi,
A Hektor,
M Kadastik,
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A Tiko,
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J Härkönen,
A Heikkinen,
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E Tuominen,
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E Tuovinen,
D Ungaro,
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K Banzuzi,
A Korpela,
T Tuuva,
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S Choudhury,
M Dejardin,
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B Fabbro,
J L Faure,
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A Givernaud,
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G Hamel de Monchenault,
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E Locci,
J Malcles,
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T Aziz,
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M Guchait,
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S M Etesami,
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S Paktinat Mehdiabadi,
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F L Navarria,
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S Carrillo Moreno,
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A Mohapatra,
I Ojalvo,
G A Pierro,
I Ross,
A Savin,
W H Smith,
J Swanson
Yerevan Physics Institute, Yerevan, Armenia.
A search for a Higgs boson in the four-lepton decay channel H→ZZ, with each Z boson decaying to an electron or muon pair, is reported. The search covers Higgs boson mass hypotheses in the range of 110<m_{H}<600 GeV. The analysis uses data corresponding to an integrated luminosity of 4.7 fb^{-1} recorded by the CMS detector in pp collisions at sqrt[s]=7 TeV from the LHC. Seventy-two events are observed with four-lepton invariant mass m_{4ℓ}>100 GeV (with 13 below 160 GeV), while 67.1±6.0 (9.5±1.3) events are expected from background. The four-lepton mass distribution is consistent with the expectation of standard model background production of ZZ pairs. Upper limits at 95% confidence level exclude the standard model Higgs boson in the ranges of 134-158 GeV, 180-305 GeV, and 340-465 GeV. Small excesses of events are observed around masses of 119, 126, and 320 GeV, making the observed limits weaker than expected in the absence of a signal.
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Yerevan Physics Institute, Yerevan, Armenia.
A search for signatures of extra spatial dimensions in the diphoton invariant-mass spectrum has been performed with the CMS detector at the LHC. No excess of events above the standard model expectation is observed using a data sample collected in proton-proton collisions at sqrt[s]=7 TeV corresponding to an integrated luminosity of 2.2 fb^{-1}. In the context of the large-extra-dimensions model, lower limits are set on the effective Planck scale in the range of 2.3-3.8 TeV at the 95% confidence level. These limits are the most restrictive bounds on virtual-graviton exchange to date. The most restrictive lower limits to date are also set on the mass of the first graviton excitation in the Randall-Sundrum model in the range of 0.86-1.84 TeV, for values of the associated coupling parameter between 0.01 and 0.10.
Rachel L Dusek,
Jamie L Bascom,
Hannes Vogel,
Sylvain Baron,
Alexander D Borowsky,
Mina J Bissell,
Laura D Attardi
ABSTRACT: INTRODUCTION: Perp is a transcriptional target of both p53 during DNA damage-induced apoptosis and p63 during stratified epithelial development. Perp-/- mice exhibit postnatal lethality associated with severe blistering of the epidermis and oral mucosa, reflecting a critical role in desmosome-mediated intercellular adhesion in keratinocytes. However, Perp's role in tissue homeostasis in other p63-dependent stratified epithelial tissues is poorly understood. Given that p63 is essential for proper mammary gland development and that cell adhesion is fundamental for ensuring the proper architecture and function of the mammary epithelium, here we investigate Perp's function in the mammary gland. METHODS: Western blot and immunofluorescence analysis were performed to characterize Perp expression and localization in the mouse mammary epithelium throughout development. The consequences of Perp deficiency for mammary epithelial development and homeostasis were examined using in vivo mammary transplant assays. Perp protein levels in a variety of human breast cancer cell lines were compared to those in untransformed cells by Western blot analysis. The role of Perp in mouse mammary tumorigenesis was investigated by aging cohorts of K14-Cre/+;p53fl/fl mice that were wild-type or deficient for Perp. Mammary tumor latency was analyzed and tumor-free survival was assessed using Kaplan Meier analysis. RESULTS: We show that Perp protein is expressed in the mammary epithelium, where it co-localizes with desmosomes. Interestingly, although altering desmosomes through genetic inactivation of Perp does not dramatically impair mammary gland ductal development, Perp loss affects mammary epithelial homeostasis by causing the accumulation of inflammatory cells around mature mammary epithelium. Moreover, we show reduced Perp expression in many human breast cancer cell lines compared to untransformed cells. Importantly, Perp-deficiency also promotes the development of mouse mammary cancer. CONCLUSIONS: Together, these observations demonstrate an important role for Perp in normal mammary tissue function and in mammary cancer suppression. In addition, our findings highlight the importance of desmosomes in cancer suppression and suggest the merit of evaluating Perp as a potential prognostic indicator or molecular target in breast cancer therapy.
Mol Biosyst. 2012 Apr 11;:
22491779
Karolina Corin,
Horst Pick,
Philipp Baaske,
Brian L Cook,
Stefan Duhr,
Christoph J Wienken,
Dieter Braun,
Horst Vogel,
Shuguang Zhang
Laboratory of Molecular Design, Center for Bits and Atoms, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139-4307, USA. Shuguang@MIT.edu.
The detergents used to solubilize GPCRs can make crystal growth the rate-limiting step in determining their structure. The Kobilka laboratory showed that insertion of T4-lysozyme (T4L) in the 3rd intracellular loop is a promising strategy towards increasing the solvent-exposed receptor area, and hence the number of possible lattice-forming contacts. The potential to use T4L with the olfactory-related receptors hOR17-4 and hVN1R1 was thus tested. The structure and function of native and T4L-variants were compared. Both receptors localized to the cell membrane, and could initiate ligand-activated signaling. Purified receptors not only had the predicted alpha-helical structures, but also bound their ligands canthoxal (M(W)= 178.23) and myrtenal (M(W)= 150.22). Interestingly, the T4L variants had higher percentages of soluble monomers compared to protein aggregates, effectively increasing the protein yield that could be used for structural and function studies. They also bound their ligands for longer times, suggesting higher receptor stability. Our results indicate that a T4L insertion may be a general method for obtaining GPCRs suitable for structural studies.
Ann Diagn Pathol. 2012 Mar 22;:
22445362
Aditya Raghunathan,
Adriana Olar,
Hannes Vogel,
John R Parker,
Susan C Coventry,
Robert Debski,
Constance T Albarracin,
Kenneth D Aldape,
Daniel P Cahill 3rd,
Suzanne Z Powell,
Gregory N Fuller
Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Pathology, The Methodist Hospital, Houston, TX 77030, USA.
Mutations of isocitrate dehydrogenase-1 gene (IDH1), most commonly resulting in replacement of arginine at position 132 by histidine (R132H), have been described in World Health Organization grade II and III diffuse gliomas and secondary glioblastoma. Immunohistochemistry using a mouse monoclonal antibody has a high specificity and sensitivity for detecting IDH1 R132H mutant protein in sections from formalin-fixed, paraffin-embedded tissue. Angiocentric glioma (AG), a unique neoplasm with mixed phenotypic features of diffuse glioma and ependymoma, has recently been codified as a grade I neoplasm in the 2007 World Health Organization classification of central nervous system tumors. The present study was designed to evaluate IDH1 R132H protein in AG. Three cases of AG were collected, and the diagnoses were confirmed. Expression of mutant IDH1 R132H protein was determined by immunohistochemistry on representative formalin-fixed, paraffin-embedded sections using the antihuman mouse monoclonal antibody IDH1 R132H (Dianova, Hamburg, Germany). Known IDH1 mutation-positive and IDH1 wild-type cases of grade II to IV glioma served as positive and negative controls. All 3 patients were male, aged 3, 5, and 15 years, with intra-axial tumors in the right posterior parietal-occipital lobe, right frontal lobe, and left frontal lobe, respectively. All 3 cases showed characteristic morphologic features of AG, including a monomorphous population of slender bipolar cells that diffusely infiltrated cortical parenchyma and ensheathed cortical blood vessels radially and longitudinally. All 3 cases were negative for the presence of IDH1 R132H mutant protein (0/3). All control cases showed appropriate reactivity. IDH1 R132H mutation has been described as a common molecular signature of grade II and III diffuse gliomas and secondary glioblastoma; however, AG, which exhibits some features of diffuse glioma, has not been evaluated. The absence of mutant IDH1 R132H protein expression in AG may help further distinguish this unique neoplasm from diffuse glioma.
Jason Karamchandani,
Hannes Vogel,
Nancy Fischbein,
Iris Gibbs,
Michael S B Edwards,
Harsh Griffith 4th
Departments of *Pathology ‡Radiology §Radiation Oncology, and ‖Neurosurgery, Stanford University Medical Center, Palo Alto, California ¶Department of Neurosurgery, Division of Pediatric Neurosurgery, Lucile Packard Children's Hospital, Stanford University, Palo Alto, California.
BACKGROUND AND IMPORTANCE : Papillary endothelial hyperplasia (PEH) is a rare form of exuberant reactive endothelial proliferation that can mimic neoplasm. We report the largest series of patients with histologically confirmed intracranial extravascular PEH developing in the field of previous treatment with stereotactic radiosurgery. CLINICAL PRESENTATION : We collected the clinical, radiological, surgical, and pathological findings from 4 patients in whom intracranial extravascular PEH developed after treatment with stereotactic radiosurgery. In all patients, the development of an enlarging hemorrhagic mass lesion at the site of previous radiotherapy on magnetic resonance imaging was radiographically suspicious for neoplasm and prompted biopsy or resection. All 4 patients elected to undergo biopsy or surgical resection. Histological examination of the biopsy and resection specimens in all patients demonstrated the classic features of PEH. CONCLUSION : The interval to the development of PEH ranged from 5 months to 6 years, 10 months. Clinical follow-up was available for 3 of the 4 patients. None of these 3 patients have demonstrated evidence of recurrence during a mean follow-up period of 22 months (range, 15-30 months). These patients share common radiological features, potentially allowing preoperative diagnosis and improved guidance of clinical management. These cases suggest a link between radiosurgery and the development of PEH. These findings also suggest that PEH should be considered in the differential diagnosis for patients treated with radiosurgery in whom a hemorrhagic mass lesion subsequently develops at or near the site of previous treatment. We think that complete surgical excision is the best treatment for intracranial PEH.
PLoS One. 2012 ;7 (2):e31238
22363592
Josep Bassaganya-Riera,
Monica Viladomiu,
Mireia Pedragosa,
Claudio De Simone,
Adria Carbo,
Rustem Shaykhutdinov,
Christian Jobin,
Janelle C Arthur,
Benjamin A Corl,
Hans Vogel,
Martin Storr,
Raquel Hontecillas
Nutritional Immunology and Molecular Medicine Laboratory, Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America.
BACKGROUND Inflammatory bowel disease (IBD) therapies are modestly successful and associated with significant side effects. Thus, the investigation of novel approaches to prevent colitis is important. Probiotic bacteria can produce immunoregulatory metabolites in vitro such as conjugated linoleic acid (CLA), a polyunsaturated fatty acid with potent anti-inflammatory effects. This study aimed to investigate the cellular and molecular mechanisms underlying the anti-inflammatory efficacy of probiotic bacteria using a mouse model of colitis. METHODOLOGY/PRINCIPAL FINDINGS The immune modulatory mechanisms of VSL#3 probiotic bacteria and CLA were investigated in a mouse model of DSS colitis. Colonic specimens were collected for histopathology, gene expression and flow cytometry analyses. Immune cell subsets in the mesenteric lymph nodes (MLN), spleen, blood and colonic lamina propria cells were phenotypically and functionally characterized. Fecal samples and colonic contents were collected to determine the effect of VSL#3 and CLA on gut microbial diversity and CLA production. CLA and VSL#3 treatment ameliorated colitis and decreased colonic bacterial diversity, a finding that correlated with decreased gut pathology. Colonic CLA concentrations were increased in response to probiotic bacterial treatment, but without systemic distribution in blood. VSL#3 and CLA decreased macrophage accumulation in the MLN of mice with DSS colitis. The loss of PPAR γ in myeloid cells abrogated the protective effect of probiotic bacteria and CLA in mice with DSS colitis. CONCLUSIONS/SIGNIFICANCE Probiotic bacteria modulate gut microbial diversity and favor local production of CLA in the colon that targets myeloid cell PPAR γ to suppress colitis.
FEMS Microbiol Ecol. 2012 Feb 22;:
22356591
Department of Bioorganic Chemistry, Max-Planck Institute for Chemical Ecology, Beutenberg Campus, Hans-Knoell-Str. 8, D-07745, Jena, Germany.
Although hematophagous black flies are well-known socioeconomic pests and vectors of disease agents, their associated bacteria are poorly known. A systematic analysis of the bacterial community associated with freshly emerged adult black flies of four North American species, using cultivation-independent molecular techniques, revealed 75 non-singleton bacterial phylotypes. Although 17 cosmopolitan phylotypes were shared among host species, each fly species had a distinct bacterial profile. The bacterial composition, however, did not correlate strongly with the host phylogeny, but differed between male and female flies of the same species from the same habitat, demonstrating that a group of insects have a gender-dependent bacterial community. In general, female flies harbor a less diverse bacterial community than do males. The anatomical locations of selected bacteria were revealed using fluorescence in situ hybridization. Understanding the physiological function of the associated bacterial community could provide clues for developing novel pest-management strategies.
Melanie G Hayden Gephart,
Elizabeth Colglazier,
Kayla L Paulk,
Hannes Vogel,
Raphael Guzman,
Michael S B Edwards
Department of Neurosurgery, Stanford University Medical Center, Stanford, Calif., USA.
Background/Aims: To review the pathological distribution of pediatric primary skull tumors, and to determine the diagnostic value of lesion location, patient age and lesion size. Methods: A retrospective chart review identified 51 consecutive pediatric patients with 54 primary skull tumors, treated between 2005 and 2010. Results: The most common diagnoses were dermoid cysts (n = 34) and fibrous dysplasia (n = 5). While dermoid tumors could reside anywhere (sensitivity = 0.41), a midline lesion had a specificity of 0.9 and a positive predictive value of 0.88. All of the fibrous dysplasia lesions were laterally placed, with a negative predictive value (NPV) of 1. Patient age < or >5 years had a high sensitivity and NPV for dermoid cysts and fibrous dysplasia, respectively. Size appeared to be sensitive (0.91, 0.8), but not specific (0.6, 0.78), with good NPV (0.8, 0.97) when considering dermoid cysts (≤2 cm) or fibrous dysplasia (>2 cm), respectively.Conclusion:Dermoid cysts followed by fibrous dysplasia are the most common primary skull tumors. Lesion location, patient age and lesion size give important clues as to the diagnosis. For the majority of cases, a clinical diagnosis based on CT is sufficient for presurgical evaluation.
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