Questions for Bioinformatics in inherited cancer syndromes.
The role of APC protein is:
| Possible answers | Correct? |
|---|---|
| degradation of alpha-catenin | no |
| degradation of beta-catenin | yes |
| degradation of E-cadherin | no |
| degradation of N-cadherin | no |
| degradation of actin | no |
No comments yet.
Lynch Syndrome may be linked with:
| Possible answers | Correct? |
|---|---|
| mutations of MMR genes | yes |
| mutations of MMN genes | no |
| MSI | yes |
| mutations of MLH1 | yes |
| mutations of MSH2 | yes |
No comments yet.
Please see this picture http://lib.bioinfo.pl/app/webroot/img/UserFiles/111569/Image/msi.JPG and do the excercise:
Please count lenghts of PCR products (peaks - the information about lenght may be found in green brackets) and decide about the analysed repeats of CA fragments:
They are...
| Possible answers | Correct? |
|---|---|
| mononucleotides | no |
| dinucleotides | yes |
| trinucleotides | no |
| pentanucleotides | no |
| there is no analysis | no |
No comments yet.
Please indicate the gene linked with HNPCC with chromosomal locus 3p21.3:
| Possible answers | Correct? |
|---|---|
| MIW2 | no |
| MLH1 | yes |
| MSH2 | no |
| APC | no |
| CDH1 | no |
No comments yet.
Wnt pathway is linked with:
| Possible answers | Correct? |
|---|---|
| APC | yes |
| MLH1 | no |
| MSH1 | no |
| MSH2 | no |
| Axin | yes |
No comments yet.
Both BRCA 1 and 2 genes are:
| Possible answers | Correct? |
|---|---|
| short genes | no |
| large genes | yes |
| comprising 25 and 27 exons, respectively. | no |
| comprising 23 and 27 exons, respectively. | yes |
| comprising 21 and 27 exons, respectively. | no |
No comments yet.
SeqMan NGen is dedicated to analyse data of:
| Possible answers | Correct? |
|---|---|
| New generation sequencing | yes |
| Illumina | yes |
| Helicos | yes |
| MitoGEN | no |
| ABI SOLID | yes |
No comments yet.
Revised Bethesda Guidelines are dedicated for:
| Possible answers | Correct? |
|---|---|
| HNPCC | yes |
| FAP | no |
| Colorectal Cancers with Microsatellite Instability | yes |
| Lynch Syndrome | yes |
| Ovarian Cancer Syndrome | no |
No comments yet.
Hereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch syndrome, is:
| Possible answers | Correct? |
|---|---|
| a rare autosomal dominant syndrome | no |
| a common autosomal dominant syndrome | yes |
| characterized by early age at onset | yes |
| characterized by very old age at onset | no |
| characterized microsatellite instability (MSI). | yes |
No comments yet.
Hereditary nonpolyposis colorectal cancer (HNPCC) is a syndrome characterized by the development of neoplastic lesions in a variety of tissues, e.g.:
| Possible answers | Correct? |
|---|---|
| endometrial | yes |
| gastric | yes |
| renal | yes |
| colon | yes |
| ovarian | yes |
No comments yet.
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