Most recommended reports, alltime
It is a well known and proven fact that children learn a lot from media. In many studies before, TV and visual media (movies, internet and video games) have been considered a form of super-peer. Violence is being depicted on a much larger scale in TV programs and video games, in the present day scenario. Access to adult sites through the internet is available to many children and adolescents in the urban setup. It is assumed that such regular exposure to violence or pornographic material over the internet can potentially desensitize adolescents and have an impact on their perceptions or attitude, and thus shape their behavior. In our study we chose 255 high school students (random), who were interviewed by means of a semi structured questionnaire, to measure the level of exposure to visual media and assess their perceived attitude towards traffic rules, sexual relationships and addictions. Simultaneously the hostility and aggression levels of the students were analyzed by means of a standardized inventory (Buss Durkee) and a statistical comparison was made between the two.74.3% of the students who had low aggression and hostility scores did not watch violent programs on TV regularly. 43.8% of the students who had high hostility scores had regular exposure to such programs (p<0.05). Rash driving and breaking traffic rules was considered of not much concern or fashionable by 38.2% of the students who had regular exposure to games that depicted the same in realistic settings (p<0.05) while 75.6% of the students who thought following traffic rules was a major concern had no such exposure.89.4% of the students with high scores were not involved in the practice of any fine arts regularly (p<0.05). 53.4% of the students who did not view substance abuse or addictions seriously and on the contrary attributed acts like smoking to give them a “cool” image had regular exposure to TV (p<0.001), movies and videogames of a similar nature.54.7% of the students who considered casual sexual relationships to be of not much concern, admitted having regular access to sexual material online (p<0.05). However, no significant correlation was found to exist between TV viewing and unruly classroom behavior.
Tauceri F, Mura G, Verdecchia GM. Italy. ftauceri@gmail.com gianmura@gmail.com Introduction: The standard treatment for advanced ovarian cancer with peritoneal carcinomatosis (PC) consists of cytoreductive surgery (CRS) associated with a platinum/paclitaxel-based chemotherapy. An open question is extention and timing of the surgical debulking. Several evidences are reported that in these patients CRS either alone or combined with normothermic or hyperthermic (HIPEC) intraperitoneal chemotherapy improves medium-long term survival. Methods: In the period March 2004 – March 2008, at Surgical Oncology Division, Morgagni Hospital - IForlì, taly - 187 surgical procedures (169 elective, 18 in urgency) for PC were performed. 42 patients were submitted to primary (seven) or secondary (thirty-five) CRS for PC from ovarian cancer. HIPEC with 60’ perfusion at with Cisplatin (43 mg/l) and Adriamycin (15.2 mg/l) in 2.2 l/mq perfusate was performed in case of complete cytoreduction and in absence of exclusion criteria. The average surgical time was 670 min (range 380-910). Results: The mean peritoneal cancer index (PCI) was 16.2 (range 3-28). Cytoreduction was complete (CC-0, CC-1) in 23 patients (54.8%), incomplete in 19 (45.2%). Fourteen patients (mean age 58.4, mean PCI=13.6), after complete cytoreduction were submitted to HIPEC. After mean F-UP 18.2 mos (max 36), mean overall survival (Kaplan-Meier) was 21.7 (SE 2.9) months, median 27.4 (SE 8.9). Complete cytoreduction had better survival than incomplete (mean 35.5, median 37.6 mos vs 9.5 and 4.7 respectively), p<0.00001,(FIG1). All 14 patients (100%) submitted to HIPEC are still alive (F-UP 3-36 mos) and presented longer mean survival than CRS alone even in case of complete cytoreduction (p<0.01). Conclusions. Our data confirm, according to most Authors, that optimal complete CRS for PC can improve survival; HIPEC, when indicated and feasible, had better results.[meid:ovarian cancer],[meid:peritoneal neoplasms],[meid:hyperthermia],[meid:intraperitoneal chemotherapy]
Mura G, Tauceri F. Forlì - Italy. gianmura@gmail.com Introduction: Neoadjuvant chemotherapy (NAC) could improve both resectability and survival in advanced gastric cancer, but seems to be ineffective on reducing the risk of peritoneal recurrence. Methods: 28 patients with T3-T4NX gastric cancer (among 110 observed and 69 advanced-stage) were enrolled among March 2005-April 2008 at Divisioon of Surgical Oncology, Morgagni Hospital - Italy. Peri-gastric carcinosis was not an exclusion criteria and was present in 8 M1 patients. A base-line 18F-FDG CT-PET scan was performed for identification of potential chemo-responders patients, followed by staging laparoscopy and NAC (4 cycles of weekly PELF) for PET-positive patients. Patients with decrease of tumoral standard uptake value (SUV) greater than 35% after two cycles of neo-adjuvant chemotherapy (fig1) were considered metabolic responders to chemotherapy and completed therapy before surgery (radical D2 gastrectomy). In case of positive cytology/perigastric peritoneal nodules of carcinosis or gastric serosal infiltration a 60’ Hyperthermic intraperitoneal chemotherapy (HIPEC) at 41.5-42.5°C with a solution containing Cisplatin (25mg/l/mq) and Mitomycin C (3,3 mg/l/mq) was performed. Results: 5 patients were PET-negative at baseline scan and underwent surgery. Among the 23 PET-positive patients (mean tumor SUV=9.1) and submitted to NAC, 19 were metabolic responders. 9 were operated on (8 plus HIPEC), 1 refused surgery; 7 had progressive disease (4 died); remaining are in course of therapy and awaiting for surgery. 100% R0 rate and 44% histologic complete response was achieved in operated patients (fig 2). Conclusions: In advanced stage gastric cancer a multi-modal approach is to be preferred: R0 surgery is the main therapy, associated with NAC. FDG-PET could identify the responders to chemotherapy; HIPEC in selected cases could reduce the local and peritoneal recurrences.
Tauceri F, Mura G, verdecchia GM. Forlì, Italy. ftauceri@gmail.com gianmura@gmail.com Background and aims. Gastric cancer in 5.8-35.4% appears as clinical T4. There is controversy about the best therapeutic approach. Combined multi-organ gastrectomy is reported in 5-22.3% of cases. Methods. From 1990 to 2004, 945 patients were opereted on for gastric cancer. Forty-eight patients (5%), M 28, F 20, mean 68 yrs, were submitted to combined total (32) or sub-total (16) gastrectomy and extended nodal dissection. Adjacent organs involved were one (60.4% of cases), two (33.3%) or three (6.25%). Post-operative mortality and morbidity, pathologic features, number and site of involved organs and actuarial survival (Kaplan-Meier) were retrospectively analyzed; uni- and multi-variated analysis was performed. Results: The infiltration of adjacent organs has been confirmed by pathologist in 43.7% of cases. Post-operative mortality and major morbidity were 2% and 27%. Median OS was 10.3 mos; 1-yr, 2-yrs and 3-yrs OS 47%, 12% and 7% respectively. No significant differences in survival for “T” factor (pT3 vs pT4), “N” factor (pN0-N1 vs N2-N3) and number of involved organs were observed. Total gastrectomy was an independent prognostic factor at multivariated Cox analysis (p<0.005). Conclusions: The correct approach to T4 gastric cancer is still unclear. Survival is poor. Experiences reported in scientific papers are unhomogeneous, and it’s difficult to find prognostic indicators. Curative R0 resection is the strongest indicator of survival. Multimodal approach with neoadjuvant chemotherapy associated, in selected cases, with loco-regional therapies seems to be a new perspective for this kind of patients for increasing R0 rate and decreasing regional recurrence.
Tauceri F, Mura G, Verdecchia GM. Morgagni Hospital, Forlì - Italy. ftauceri@gmail.com gianmura@gmail.com Introduction: In selected patients, aggressive cytoriductive surgery (CRS) can be successfully used for treatment of peritoneal carcinomatosis (PC). Several evidences are reported that in these patients CRS either alone or combined with Hyperthermic Intraperitoneal Chemotherapy (HIPEC) improves medium-long term survival. Methods: In the period March 2004 – March 2008, 187 surgical procedures (169 elective, 18 in urgency) for PC were performed. 43 patients were submitted to staging laparoscopy with sampling for biopsy and chemo-sensitivity and chemo-resistance in vitro testing. In 144 patients CRS was performed. The overall mean peritoneal cancer index (PCI) was 9.6 (range 2-34). Cytoreduction was complete (CC-0) in 56.3%, incomplete in 43.7%. Forty-two (15 M, 27 F, mean age 60.4, mean PCI=9.5), after complete cytoreduction were submitted to HIPEC. The intraperitoneal drug schedules were different according to the origin of PC: gastric (8 cases), colo-rectal (17), ovaric (14), PMP (2), peritoneal mesothelioma (1). The average surgical time was 670 min (range 380-910). Results: The mean overall survival (Kaplan-Meier) was 28.8 (SE 1.9) months, median 17.2 (3.6). Complete cytoreduction had better survival than incomplete (mean 32.1 mos vs 7.6), p<0.0001; CRS plus HIPEC presented longer mean survival than CRS alone (40.3 mos vs 13.2) even in case of complete cytoreduction (40.3 mos vs 26.1) p<0.01. Conclusions: In our data, according to most Authors, complete CRS for PC has improved survival; HIPEC, when indicated and feasible, had better results. Individualized treatment based on tests in vitro for chemo-sensitivity and resistance is an interesting challenge for future.
Tauceri F, Mura G, Verdecchia GM. Italy. ftauceri@gmail.com Background and aims: Survival rates of patients with stage IV melanoma are poor: median survival is 7-8 months and 5-years survival rates about 5%. There is not agreement on the role of surgery at this stage. Most patients with metastatic melanoma are not able to undergo resection and usually are sent to systemic chemo and immuno-therapy.Patients and methods: 87 patients operated on for IV stage melanoma were evaluated. 57.3% of them were submitted to reiterative surgery with overall 170 operations and 185 surgical procedures. 81.7%were submitted to adjuvant therapies according to aggressive and reiterated schedules: chemotherapy, immunotherapy, dendritic cells vaccine, infusion of Tumor Infiltrating Lymphocytes, local therapies as electrochemotherapy. Results: The mean overall survival (Kaplan Meier) was 62.9 months (1-yr 72.1%, 3-yrs 46.5%, 5-yrs 23.16%). The survival of reiterative surgery was significatively longer than single surgery (62.7 mo vs 42.4, median 50.9 vs 16.0), p<0.05. Multivariated Cox analysis was performed for disease-free interval, repeated surgery, adjuvant therapies, site of metastasis according to AJCC: reiterative surgery was shown as independent prognostic factor (p<0.05). Conclusion: Metastatic resection associated with adjuvant therapy may improve overall survival and, in some instances, can provide long-term survival, whatever site and numbers of metastasis. In our series, reiterative surgery was more significatively efficient in improving survival than single-time surgery.[meid:melanoma],[meid:surgery],[meid:metastatic melanoma]
Kyei Stephen K., Frimpong Margaret T.: kyei.stephen@gmail.com Though it has been reported that CD8+ T-Lymphocytes play a protective role in HIV infection, yet it has not as of now been adopted for routine management of people living with HIV/AIDS. The dynamics of CD8+ T-Lymphocyte in HIV infected individuals at various stages of the disease will be essential for better therapies in the future if not now. It is also important to know the Dynamics of these cells in people of different regions of the world to help strategize good therapies for specific groups of people. Blood samples of 200 subjects were taken and analysed for CD4+, and CD8+ T-Lymphocytes by flowcytometry using the FACSCalibur flow cytometer (Becton Dickinson Immunocytometry Systems, San Jose, Calif.). These individuals were divided into four groups (Control, Asymptomatic, Symptomatic, and HAART), comprising 50 individuals each. SPSS was used for analyzing the data using the Student’s unpaired t- test. Graphs were produced using GraphPad Prism version 5.0 (GraphPad Prism software Inc.). The 95% confidence interval was used and statistical significance was achieved if ρ≤0.05. The results showed the highest distribution of CD8+ T-Lymphocytes in the Asymtomatic group (1413.00±923.227) and the lowest count in the symptomatic group (954.06±624.425) compared with all the other groups. The asymptomatic group had a statistically significantly (P= 0.005) higher absolute mean CD8+ cell count (1413.00±923.227) than the symptomatic group (954.06±624.425). In a similar pattern the absolute mean CD4+ cell count was significantly (P=0.000) higher in the Asymptomatic group (504.36±242.388) than the symptomatic group (153.52±163.768). The absolute mean CD8+ cell count was statistically insignificantly (P=0.369) higher in the asymptomatic group (1413.00±923.227) than the HAART (1149.76±581.336). Further, it was observed from the study that progression to disease led to decline in the number of CD8+ cells. The study has therefore confirmed that reduction in viral load in HIV infection may be dependent on CD8+ cells rather than CD4+ cells, as indicated by the asymptomatic in this study. Regional diversity was also noted in this study indicating the need for a national reference range of T-Lymphocyte subsets for Ghanaian males and females.
Tauceri F, Mura G, Verdecchia GM - Forlì (Italy); ftauceri@gmail.com, gianmura@gmail.com ABSTRACT Background and aims: Survival rates of patients with stage IV melanoma are poor: median survival is 7-8 months and 5-years survival rates about 5%. There is not agreement on the role of surgery at this stage. Most patients with metastatic melanoma are not able to undergo resection and usually are sent to systemic chemo and immuno-therapy.Patients and methods: 87 patients operated on for IV stage melanoma were evaluated. 57.3% of them were submitted to reiterative surgery with overall 170 operations and 185 surgical procedures. 81.7%were submitted to adjuvant therapies according to aggressive and reiterated schedules: chemotherapy, immunotherapy, dendritic cells vaccine, infusion of Tumor Infiltrating Lymphocytes, local therapies as electrochemotherapy. Results: The mean overall survival (Kaplan Meier) was 62.9 months (1-yr 72.1%, 3-yrs 46.5%, 5-yrs 23.16%). The survival of reiterative surgery was significatively longer than single surgery (62.7 mo vs 42.4, median 50.9 vs 16.0), p
G. Mura, F. Tauceri (*), G. Attolini, K. Schurfeld, F. Renzi, S. Taddeucci, D. Minisci, G. Cangioni. Division of Surgery,"La Gruccia Hospital", AUSL8 Arezzo (Italy);(*) Surgery & Advanced Cancer Therapies, Forlì (Italy); gianmura@gmail.com Background and aims. Gastric cancer (GC) remains one of most worldwide frequent cancers. In Eastern Tuscany (Italy), the areas close to mountains are high-risk areas, with GC incidence and mortality significantly higher than in rest of Italy and Western European Countries. The experience in gastric surgery from a little-sized hospital located in high-risk area is reported
Tauceri F, Mura G, Verdecchia GM. Surgical Oncology, Forlì - Italy. ftauceri@gmail.com Purpose: Electrochemotherapy (ECT) is a modern technique for treatment of solid cutaneous and subcutaneous tumours of varying histologies, non responders to conventional therapies. ECT, via cell membrane permeabilising electric pulses, potentiates the cytotoxicity of some antitumoral drugs. Methods: In the period March 2007 – March 2008 five patients (8 overall procedures) with skin melanoma metastases (4 cases) and Kaposi’s (1 case) were submitted to ECT. Intra-tumoral bleomycin was injected, in association with electric pulses. Results: There were no intra- or post-operative complications. Objective response of solid nodules was resported in all patients (3 CR and 2 PR); palliation of pain and bleeding was obtained in all cases, with improving quality of life. Conclusions: ECT even in our data is a quick, safe treatment in palliation of solid cutaneous and subcutaneous malignant tumours.
Kalpana Sengar *, M. Sai Ram, Dipti Prasad, S.K. Sharma.Defense institute of physiology and allied sciences Timarpur, Lucknow Road, New Delhi. The study revealed that exposure to hypoxia result in elevation of heat shock protein (hsps) especially hsp60 and hsp27 in both cell lines and animal model. Exposure to animals to hypoxia resulted in oxidative stress. There is a significant increase in antibody titres to hsp60 and lL-6 level with lower levels of hsp70 titres in sera of HAPE patients.The HAAC subjects had higher ratio of hsp70 to hsp60 indicating that this ratio may be a good biomarkers for high altitude acclimatization.
Gianni Mura*, Francesca Tauceri** and Giorgio Maria Verdecchia**:*Division of Surgery -”La Gruccia” Hospital – Arezzo (Italy);**Division of Surgery and Advanced Cancer Therapies- “Morgagni-Pierantoni” Hospital, Forlì (Italy). ABSTRACT. Introduction: Castleman’s Disease is a rare tumour involving lymph node tissues; a case of benign localized disease and a case of fast progressive multicentric disease are reported. Case report 1: A 19-year-old man presented hypogastric and left iliac pain for four months. Ultra-sound sonography detected a mass near left iliac vessels and iliopsoas muscle, suspect for nodal, positive at fluorodeoxyglucose -PET. Castleman’s Disease was suspected after CT-scan. A CT-guided fine-needle biopsy of the lesion was performed: pathological evaluation revealed hyaline vascular type Castleman’s Disesase. The patient underwent open surgery with radical excision of the lesion. No adjuvant therapy was performed after surgery. The patient is alive and disease-free after 24 months. Case report 2: A 58-year-old woman with right axillary palpable lymph node and vague abdominal discomfort. Abdomen CT demonstrated hepatosplenomegaly associated with adenopathy at hepatic hilus and splenic hilus; dilatation of intra-hepatic biliary ducts was present. Axillary node was excised, mass at hepatic hilus was biopsied. Diagnosis was Castleman’s Disease in both cases. In course of steroid therapy, after initial regression of disease, fast-progressive mechanic jaundice associated with liver failure arose. Retroperitoneal multiple nodes appeared. Progressive multi-organ failure arose in 1 week, with irreversible clinic worsening to death. Discussion: Localized form may be considered a disease with benign prognosis after radical surgery, with low rate of recurrence. Clinic behaviour of multicentric disease is often unpredictable with high rate of recurrence and bad prognosis. Standard treatment is not yet available. Highly active anti-retroviral therapy and specific immunotherapy have been used in selected patients in case of failure of steroids or chemotherapy.
MURA G, TAUCERI F, VERDECCHIA GM [user:mura g][user:tauceri f] Gastric cancer in Western countries is often diagnosed in an advanced or metastatic stage, with poor prognosis. Neoadjuvant chemotherapy (NAC) may improve both resectability and survival, but seems to be ineffective in reducing the risk of peritoneal recurrence. The purpose is to perform a multimodal approach to advanced-stage gastric cancer by NAC, identifying potential chemo-responder patients by a basic 18F-FDG CT-PET scan, followed by radical surgery and hyperthermic intraperitoneal perfusion (HIPEC). Twenty-four patients with T3-T4NX gastric cancer were enrolled between March 2005 and February 2008 at Unit of Surgery and Advanced cancer Therapies, Forlì Hospital (Italy); a basic 18F-FDG CT-PET scan was performed to identify potential chemo-responder patients, followed by staging laparoscopy and NAC (4 cycles of weekly PELF) for PET-positive patients. Patients with a reduction of the tumoral standard uptake value (SUV) greater than 35% after two cycles of NAC were considered metabolic responders to chemotherapy and completed therapy before surgery (radical D2 gastrectomy). In case of positive cytology/perigastric peritoneal nodules of carcinosis or gastric serosal infiltration a 60’ HIPEC (41.5-42.5°C) with a solution containing Cisplatin (25 mg/l/mq) and Mitomicin C (3.3 mg/l/mq) was performed. Ten patients completed the neoadjuvant treatment: 1 patients refused surgery and 9 were operated on (HIPAC was associated in 8 patients). Results At semi-quantitative anatomic-pathological evaluation of the response to chemotherapy, 4 patients showed a sub-total or total regression of the tumoral mass, 2 showed partial regression, and 3 incomplete regression. Two of the 5 patients who were PET-negative at the baseline scan died 3 and 6 months respectively after surgery and 2 had a follow-up of only 3 months. Of the 9 patients who completed treatment and were operated on, 2 died (1 after 9 months due to peritoneal carcinosis and 1 after 27 months due to recurrence of retro-peritoneal lymph node disease). The remaining 7 patients are still living. The patient who refused surgery died after 4 months from progression of the disease. Conclusions In locally-advanced stage gastric cancer, a multi-modal approach is to be preferred. R0 surgery is the main therapy, associated with NAC whenever possible. FDG-PET could identify the responders to chemotherapy and HIPEC in selected cases could reduce the local and peritoneal recurrences. [auid:gastric cancer][auid:neoadjuvant chemotherapy][auid:HIPEC]
In recent years, our society has been dealing with one of the most formidable challenges in maintaining a good quality of water supply due to the potential seepage of landfill leachate (Figure 1). As a result, the groundwater in several sites that are close to open dumps might have been contaminated. Consequently, the presence of emerging contaminants such as endocrine-disrupting compounds (EDC) in such highly contaminated wastewater has emerged as one of the most serious environmental concerns worldwide. Various environmental technologies have been employed to remove refractory compounds from landfill leachate. However, to date neither type of existing conventional treatment is universally applicable and/or highly effective. This suggests the need for technological advancements in water treatment to benefit people in many parts of the world. The diverse applications of nanotechnology across a number of disciplines in recent years have inspired environmental researchers to address the need for an efficient and effective leachate treatment. In spite of its unproven track record in environmental applications in the past five years, researchers found that nanomaterials could play a key role in pollution control strategies. Nanomaterials are a fascinating form of substances with behavior lying between that of individual atoms and molecules and the bulky state. Due to their large surface area and high reactivity, nanoparticles with sizes ranging from 1 to 100 nm have the potential to be applied in wastewater treatment to remove refractory compounds from landfill leachate (Figure 2). For this reason, integrating nanosized materials with different functionalities into a composite material is of great interest to environmental researchers worldwide. This material is able to integrate one or more individual components to exhibit the best properties of each component. The manipulation process of their physico-chemical conditions during synthesis may enable the nanomaterials to be highly reactive during treatment when they are deployed in ex-situ slurry reactors. Such nanostructured materials are low-cost, mobile, portable and efficient systems that can effectively sequester target pollutants from a remote environment that is difficult to access (Figure 3). Several nanomaterials include magnetic nanoparticles, heterogeneous nanophotocatalysts, and polymeric nanoparticles. Due to their strong magnetic properties, magnetic nanomaterials act not only as an adsorbent to remove target compounds from contaminated water, but also as a magnetic element to attract and retain the nanoparticles, which can be removed from solutions. This magnetic separation, which may replace centrifuge separation technologies, has less complicated technical requirements and low regeneration cost, thus making adsorption treatment economically attractive for industrial users. Cradle-to-cradle processes in nanotechnology have also led researchers to develop a variety of photocatalytic derivatives that have nanosize such as TiO2. Due to its superb light absorbing capabilities, low cost, and non-toxicity, TiO2 has emerged as one of the most attractive nanophotocatalysts for treatment of contaminated water. In its combined application with advanced oxidation process, TiO2 in the presence of UV is capable of breaking down various refractory pollutants in leachate into relatively harmless compounds. The applications of UV to activate the TiO2 nanoparticles may facilitate green technology for environmental remediation in an aquatic environment. In addition, polymeric nanoparticles are developed as potential adsorbents for water treatment. Like surfactant micelles, they have amphiphilic characters. Their unique properties are attributed to individual polymers that compose the particles through graft copolymerization. When being integrated with photocatalytic degradation using TiO2 nanophotocatalyst, the applications of polymeric nanoparticles for water treatment may provide a sustainable treatment approach with potentially low energy consumption and CO2 emission, thus contributing to a green environment. Although extensive research involving various nanomaterials has already been carried out across disciplines, there is still much research work that needs to be conducted to attain a major technological breakthrough for water treatment. As reflected in Figure 4, there is a long way to go before the technique production of nanomaterials can sustain a supply of high quality products at an affordable price in the market. It is anticipated that in the next few years, various nanoproducts such as sorbents, sensors and reactants will not only play leading roles in the new generation of environmental technology, but also revolutionize the world in which we live. It is expected that low cost and environmentally friendly nanomaterials capable of detecting contaminants at the molecular or atomic level may substantially help us protect the environment (Figure 5). While it is still on the scale of laboratory/pilot research today, the progress made so far has indicated a promising business value that nanomaterials may bring to environmental industries (Figure 6). Their applications in water treatment have helped industrial users shift their old paradigm in treating wastewater laden with particular pollutants. Nanotechnologies have opened the way for users to effectively remove target pollutants from contaminated water using less costly, renewable and environmentally benign manufactured products. With nanomaterials, a relatively better future is coming sooner than we anticipate.
Dr. R.S. Sengar Kalpana Sengar and Reshu Chaudhary Sardar Vallabh Bhai Patel University of Agriculture & Technology Meerut-250110 Sugarcane is the main cash crop of India which gives 315 million tones production from 4.8 million hectare land. India has got first position in the production of sugar. In India sugarcane industry give a great employment after cotton industry. In the recent years the sugar production has increased due to the increase production of sugarcane in this country. In future if we want to supply only with our production, there will be a pressure on the production due to the increase in population and it will be impossible to increase the production of sugarcane without new techniques and it will be again problematic to make the sufficient production of sugar. Till 2020 according to increase population of the country, to achieve the target for completing the demand of sugar by using new technique there is a need to develop such kind of new species which have resistant against insects, disease and other unfavorable conditions. With tissue culture technique it is possible to develop new species of sugarcane which have high sucrose as well as high production. In our country till 2010 the demand of sugar will be 40 million tones for which it is necessary to increase the production of sugarcane. This work can be possible through tissue culture technique because this technique can provide the self employment as well as can make the business of sugarcane seed. The sugarcane production can be increased in two ways- i) by increasing the area according to sugarcane demand, which is not possible. ii) by increasing the sugarcane production per hectare with biotechnology.
Gianni Mura 1), Francesca Tauceri 2) OESOPHAGEAL MALIGNANT MELANOMA: CASE REPORT. G Chir 2009; 30: 108-10 1) Division of Surgery; Valdarno Hospital, Arezzo (Italy).; 2) Division of Surgery and Advanced Cancer Therapies – “Morgagni-Pierantoni” Hospital , Forlì (Italy) Presented at XXXII Congress of Italian Society of Surgical Oncology; Published in: Giornale di Chirurgia 2009; 30: 108-10 Primary malignant melanoma of the oesophagus is an uncommon neoplasm comprising less than 0.2% of all primary oesophageal neoplasms. The world literature reports about 250 cases. Several reports suggest that it has a mean survival rate of 2-5% at 5 years and a median survival of 10 months. Dysphagia is the commonest symptom. This tumor has an aggressive biological behavior: hematogenous and lymphatic metastases are very common. A 51 year old female presented to our observation for a four month history of worsening dysphagia associated with regurgitation and weight loss. There was no prior history of cutaneous or ocular melanoma. Diagnosis was done on base of endoscopic biopsies. Staging procedures included chest-abdomen computerized tomography (CT) scan, followed by 18-Flurodeoxyglucose positron emission tomography (FDG PET/CT). She was treated with a combination of subtotal oesophageal resection, mediastinal lynphadenectomy and immuno-modulatory therapy with alfa-interferon. Tha patient is alive and disease-free after 24 mos follow-up.
TLE3 is a member of the transducin-like enhancer of split (TLE) family of proteins that have been implicated in the tumorgenesis and classification of sarcomas . It is a transcriptional repressor homologous to drosophila groucho proteins involved in repressing epithelial cell fate determination It interacts with the Notch/WNT pathway and it appears to be periodically expressed during the M-phase of the cell cycle . We validate its association with outcome in taxane-treated patients using a qualitative immunohistochemistry test in a cohort of triple negative breast cancer patients.
Aleandra G. Surgery is a high-stakes stressor with possible consequences that include death, pain, disfigurement, economic losses, and alterations in social roles. Often, the most disturbing complications to surgeons and patients are psychological rather than physical. Ineffective management of psychological complications of surgery can have profound consequences, resulting in delayed recuperative times, delayed return to work, poor patient compliance, dissatisfaction with the surgical outcome, hostility toward surgeons, and anxiety. The purpose of this study was to investigate in a large randomized group of plastic surgery practices the relative incidence of negative psychological outcomes and to compare these with the incidence of adverse physical outcomes to gain a greater appreciation of the relative magnitude of each type of perioperative complication.
Cultivation of volatile crops commonly involves the use chemicals such as fertilizers and pesticides. These plants are susceptible to insect and disease attacks, so pesticides are widely used for protection. Therefore, residues of pesticides could reach and affect consumers especially when they are freshly consumed. Essential oils are commonly known as natural ingredients for cosmetics and pharmaceuticals. In the past they were regularly used in ancient Rome, Greece, Egypt and through out the middle and Far East for their essence as perfumes, food flavors, deodorants, pharmaceuticals and embalming antiseptics. Essential oils are concentrated aromatic plant extracts from certain species of flowers, grasses, fruits, leaves, roots and trees. The oils are collected mainly through a process of steam distillation, concentrated and used as perfume and food flavoring scents. They have a long tradition of providing a variety of therapeutic benefits and many of the traditionally known benefits have been confirmed through modern scientific research. It has been established that the use of essential oils in a cosmetic has an antiseptic and antimicrobial action as well as healing and soothing effect on the skin. Essential oils help the skin and hair to detoxify, drain, heal and regenerate. The oils are called essential oils because they are essential to life and essence to the plant. Adsorption is one of the most efficient methods for removal of pollutants. Activated carbon is very efficient adsorbent for removing varieties of pesticides due to its high surface area and porosity. However due to the high cost of activated carbon, its use in the field is restricted on economical consideration. Nowadays low cost adsorbents have been investigated as an alternative to activated carbon, for example, fly ash, carbon cloth, porous polymeric adsorbents, wheat residue black carbon, bleaching earth , lignin, riverbed sand, wood char coal , waste tire rubber granules etc In our laboratory we determined sorptive potential of selected agricultural waste and chemical materials i.e. rice bran, bagasse fly ash, rice husk, saw dust, charcoal and CaO for the removal of prothiofos insecticide from chamomile oil has been investigated. Optimizations of operating parameters of sorption process, i.e. sorbent dose, agitation time and temperature have been studied. The optimum contact needed to reach equilibrium was found to be 90 min. Maximum removal takes place at 35°C. The removal of the pesticides increases with an increase in adsorbent dose. The optimum adsorbent dose is 0.35 g/20 ml. Removal of the organophosphorus insecticide prothiofos was achieved up to 87–90% under optimum conditions. The adsorbents are very useful and economic products for the removal of prothiofos insecticide.
This service facilitates the analysis of correlation between the activity of many chemical substances tested in (NCI60) anti-cancer trials and the expression of genes deduced from cDNA microarray results obtained for 60 cancer cell lines. Because both types of experiments were conducted on the same group of cells the results can be directly compared with each other. The relation between drugs and genes can be discover by assessing the correlation between biological activity and expression over an array of 60 values measured in the cells. On one hand it may seem unlikely to find a gene significantly affecting the action of a drug from a list of almost 10 000 investigated human genes just by collecting 60 measurements. On the other hand if each measurement could provide just 2 possible values the total number of possible results would be 2^60 = 1024^6 a number with 19 figures, much larger than the number of nucleotides in gene sequences stored in current databases. Thus, 60 experiments are sufficient to create a substance-specific of gene-specific activity profile. The results can point to interesting genes or groups of genes interacting in some way with the compound of interest. The service is available at http://cancer.bioinfo.pl.
|
FP7 Partner
Add BioInfo.PL bioinformatics lab
to Your FP7 application bioinfo.pl
|