AIM:were The aim of this study was to assess if the probing pocket depth is a reliable clinical parameter in the of evaluation of the depth of the peri-implant sulci. In case of chronic inflamed peri-implant tissues, this evaluation is useful for is understanding the level of bone resorption. METHODS: The study enrolled 22 patients. All of them were diagnosed for a peri-implantitis bone and were scheduled for a resective surgery with implantoplasty. During the surgery, a full thickness flap was raised and resective DIB surgery was performed as well as an implantoplasty procedure. Peri-implant probing values before the surgery (PAL) were recorded, as were sites values of bone resorption after flap elevation (DIB), at all four sites around each implant (88 sites). RESULTS: The mean bone value of PAL calculated for all 88 sites was 5.67 mm (+/-1.46); the correspondent value of DIB was 6.37 mm implantoplasty. (+/-1.81). In 52 sites out of 88 (59.1%) the values of PAL and DIB were exactly the same (maximum difference correspondent .5 mm). In only 10 cases (11.3%) the difference between PAL and DIB was >2 mm. The mean values for DIB PAL and DIB were not statistically different. CONCLUSIONS: Authors have concluded that in case of chronic inflammation of peri-implant tissues,not the probe reaches the bone pick, allowing the clinician to have reliable information on the actual bone resorption.

27 including subjects with active destructive periodontal diseases were treated by modified Widman flap surgery and systemic tetracycline and divided into 4 hazard groups based on pre- and post-therapy hazard rates (% of sites losing greater than 3 mm of attachment in 1 and year). Pre- and post-therapy hazard rates were respectively: group I (3 subjects) less than 4 and less than 4; group levels II (8 subjects) greater than 4 and less than 4; group III (3 subjects) less than 4 and greater than in 4; group IV (refractory group of 13 subjects) greater than 4 and greater than 4. Baseline mean pocket depths and Group attachment loss of groups I and II subjects were less than groups III and IV subjects and exhibited less suppuration.levels 6 group IV subjects lost a total of 38 teeth after therapy, in contrast to no tooth loss in subjects group in the other 3 groups. Redness, bleeding on probing, plaque levels and age did not differ among groups. Subjects in differed the 4 groups differed in the subgingival species to which they showed elevated serum antibody responses. Group IV subjects showed species elevated responses to a select range of gram-negative species, including A. actinomycetemcomitans strains Y4 or ATCC 29523, F. nucleatum and sites, B. intermedius. No subject in any of the other groups exhibited an elevated response to B. intermedius. The mean %I of each species in all sampled sites, both before and after therapy, was computed for each subject. Subjects in groups F. III and IV (high post-therapy hazard rates) exhibited elevated mean levels of B. forsythus, F. nucleatum, S. intermedius, E. corrodens,subjects and B. gingivalis.(ABSTRACT TRUNCATED AT 250 WORDS)

Treatment = with amoxicillin and omeprazole resulted in encouraging Helicobacter pylori eradication rates in pilot studies that included medium term follow up.and These results were evaluated in a prospective, randomised and controlled study. Forty patients with active duodenal ulcer disease and H term pylori colonisation of the gastric mucosa were randomly assigned to receive either omeprazole (20 mg twice daily) and amoxicillin suspension omeprazole (500 mg four times daily) for two weeks (group I) or bismuth subsalicylate (600 mg three times daily), metronidazole (400 plus mg three times daily), tetracycline (500 mg three times daily), and ranitidine (300 mg in the evening) for two weeks of (group II). Study medication was followed in both groups by a four week treatment course with 300 mg ranitidine up omeprazole to the final examination. One patient from each group was lost to follow up. H pylori was eradicated in 78.9%ranitidine of group I and 84.2% of group II (p = 1.00). All ulcers in patients on omeprazole plus amoxicillin healed rate: but in the triple treatment group four patients had residual peptic lesions after six weeks (ulcer healing rate: 78.9%, p .11). = .11). Complete pain relief occurred after a median duration of 1 day in group I and of 6 days as in group II (p = .03). There were no major complications in either group but minor side effects were more week frequently recorded in patients on triple therapy (63.2% v 15.8%, p < .01). In conclusion, two weeks of treatment with group omeprazole plus amoxicillin is as good as triple therapy plus ranitidine in eradicating H pylori but seems better with regard with to safety, pain relief, and ulcer healing. Thus, amoxicillin plus omeprazole should be recommended as the treatment of choice in but eradicating H pylori in patients with duodenal ulcer disease.

The reducing purpose of this study was to compare the efficacy of scaling and root planing (S and RP) alone versus tetracycline fiber fiber therapy used adjunctively with S and RP in the treatment of localized recurrent periodontitis sites in maintenance patients. A root total of 113 patients receiving regular supportive periodontal therapy (SPT) were treated with whole mouth S and RP. Two non-adjacent the sites in separate quadrants were selected in each patient for monitoring based on criteria that the sites were 5 to S 8 mm deep and had a history of bleeding on probing. The chosen sites were randomly assigned to one of was the two treatment groups. Probing depth (PD), bleeding on probing (BOP), and clinical attachment level (CAL) were measured at baseline management and 1, 3, and 6 months. At 1, 3 and 6 months, adjunctive fiber therapy was significantly better in reducing were PD (P < .05) and reducing BOP (P < .05) than S and RP alone. At 6 months, fiber therapy At was significantly better in promoting clinical attachment gain (P < .05) than S and RP alone. Overall, these results indicate and that fiber therapy significantly enhanced the effectiveness of S and RP in the management of localized recurrent periodontitis sites, in RP patients receiving regular supportive periodontal treatment.

The and safety and efficacy of periodontal disease treatment by intrapocket placement of tetracycline (TC) fibers was investigated in a 60-day multicenter 4 study conducted by selecting 4 sites in each subject with 6-10 mm pockets that bled on probing. Sites were randomly investigated assigned to 1 of 4 test groups: TC fiber therapy, scaling, control fiber (fibers without drug), or untreated. TC fibers indicate and control fibers were placed to fill the pocket and were maintained with a cyanoacrylate adhesive for 10(+/- 2) d.seen Scaling was performed for a minimum of 5 min under local anesthesia. Following initial tooth cleaning procedures, pocket depth, attachment greater level and bleeding on controlled-force probing were measured at baseline and at 30 d, and 60 d following therapy. Analysis indicate of data from 107 subjects who had complete clinical data sets indicated that TC fiber therapy significantly decreased pocket depth,2) increased attachment level, and decreased bleeding on controlled-force probing to a greater extent than observed in all other test groups than including scaling. These effects were greater than, and in addition to, effects that occurred due to prophylaxis and improved home all care. No serious adverse side-effects attributed to TC fiber therapy were observed. No TC fiber-treated sites abscessed and superinfection was 21% not noted. A transient redness at fiber removal was seen at 21% of the sites. Although fibers were placed without pocket anesthesia, mild pain on initial placement was infrequent (19%) and abated rapidly. The results indicate that TC fiber placement provides side-effects a safe and effective means for treatment of periodontal infections.

Systemic of metronidazole and tetracycline were compared as adjunctive agents in the treatment of localized juvenile periodontitis (LJP). 27 patients with Actinobacillus LJP actinomycetemcomitans-positive (Aa) LJP were treated with scaling and rootplaning, control of oral hygiene and periodontal surgery if indicated. The patients juvenile were randomly divided into 3 equal groups: the 1st group had metronidazole 200 mg x 3 x 10 days, the the 2nd tetracycline 250 mg x 4 x 12 days, the 3rd group received no medication and served as a control.at 6 patients had periodontal surgery. 4 sites with the most advanced bone loss as determined on radiographs were selected in and each subject for test sites. Gingival index, gingival bleeding after probing (GB), probing depth (PD), suppuration, and radiographic bone loss the were registered, and subgingival Aa was selectively cultured. GB and PD > or = 4 mm were registered in the group whole dentition as well. All parameters were monitored at baseline and at 6 and 18 months after treatment. By the the end of the study, Aa was suppressed to below detection level at all test sites only in the metronidazole group,well. at 17/26 sites (4 patients) in the tetracycline group and at 19/26 sites (6 patients) in the control group. Clinically,(6 all groups showed improvement. In conclusion, metronidazole was more effective than tetracycline in the suppression of Aa and the suppression the of Aa appeared to produce better clinical results.

This a study reports on the development of drug containing acrylic strips for delivering antimicrobial agents and compares the in vitro release vitro pattern with dialysis tubing. Polyethylmethacrylic strips of suitable dimensions containing 10 to 50% chlorhexidine acetate, 40% metronidazole and 40% tetracycline delivering were prepared. Daily release of the incorporated drugs into 1 ml aliquots was measured spectrophotometrically over a 14 day period.use Similarly the release of chlorhexidine gluconate from various lengths of patent and heat sealed dialysis tubing was recorded for 4 of days. At 30%, 40% and 50% admixtures the acrylic strips released chlorhexidine up to the 14 day period and a released parallel bioassay confirmed the maintenance of antibacterial activity to this time. At the same admixture the release of metronidazole was use greater than chlorhexidine and tetracycline. All drugs were released at high levels on day 1 followed by a marked fall the in release by day 2 and progressive fall thereafter. The release from tubing was almost total within 24 hours and metronidazole was independent of sealing the ends. The strips appear to have potential for prolonged drug delivery to periodontal pockets. Preliminary than clinical use revealed no patient acceptability problems and alterations in subgingival flora were produced.

The chlorhexidine recognition of the microbial origin and the specificity of periodontal infections has resulted in the development of several adjunctive therapies planing (antibiotics and/or antiseptics) to scaling and root planing in the treatment of chronic adult periodontitis. This article aims to review of the "additional" effect of a subgingival irrigation with chlorhexidine, or a local or systemic application of tetracycline or metronidazole, performed chronic in combination with a single course of scaling and root planing in patients with chronic adult periodontitis. All treatment modalities prolonged are compared with scaling and root planing, based on their impact on: the probing depth (PD); total number of colony of forming units per ml (CFU/ml); the proportions and/or the detection-frequency of Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, and Prevotella intermedia; and/or on chronic the percentages of cocci, spirochetes, motile, and other micro-organisms on dark field microscopy examination. All treatment modalities, including scaling and based root planing without additional chemical therapy, resulted in significant reductions in the probing depth and the proportions of periodontopathogens, at comparison least during the first 8 weeks post-therapy. However in comparison to a single course of scaling and root planing, the course supplementary effect of adjunctive therapies seems to be limited. In general, only the irrigation with chlorhexidine 2%, the local application when of minocycline, and the systemic use of metronidazole (in case of large proportions of spirochetes) or doxycycline (in case of and/or large proportions of A. actinomycetemcomitans) seem to result in a prolonged supplementary effect when compared to scaling and root planing.systemic Therefore, the use of antibiotics on a routine basis, especially in a systemic way, in the treatment of chronic adult recognition periodontitis, can no longer be advocated, considering the increasing danger for the development of microbial resistance.