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Proc Natl Acad Sci U S A. 2004 Jul 6;101 (27):9966-70 15226508 (P,S,G,E,B,D) Cited:14
Quantum-Phase Electronics Center, School of Engineering, University of Tokyo, Tokyo 113-8656, Japan. someya@ap.t.u-tokyo.ac.jp
It transistors is now widely accepted that skin sensitivity will be very important for future robots used by humans in daily life even for housekeeping and entertainment purposes. Despite this fact, relatively little progress has been made in the field of pressure recognition as compared to the areas of sight and voice recognition, mainly because good artificial "electronic skin" with a large area and would mechanical flexibility is not yet available. The fabrication of a sensitive skin consisting of thousands of pressure sensors would require solution a flexible switching matrix that cannot be realized with present silicon-based electronics. Organic field-effect transistors can substitute for such conventional little electronics because organic circuits are inherently flexible and potentially ultralow in cost even for a large area. Thus, integration of been organic transistors and rubber pressure sensors, both of which can be produced by low-cost processing technology such as large-area printing electronics. technology, will provide an ideal solution to realize a practical artificial skin, whose feasibility has been demonstrated in this paper.housekeeping Pressure images have been taken by flexible active matrix drivers with organic transistors whose mobility reaches as high as 1.4 circuits cm(2)/V.s. The device is electrically functional even when it is wrapped around a cylindrical bar with a 2-mm radius.

Latest citations:

Nat Mater. 2009 May 10;: 19430465 (P,S,G,E,B,D)
Quantum-Phase Electronics Center, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
Stretchability light-emitting will significantly expand the applications scope of electronics, particularly for large-area electronic displays, sensors and actuators. Unlike for conventional devices,spread stretchable electronics can cover arbitrary surfaces and movable parts. However, a large hurdle is the manufacture of large-area highly stretchable could electrical wirings with high conductivity. Here, we describe the manufacture of printable elastic conductors comprising single-walled carbon nanotubes (SWNTs) uniformly carbon dispersed in a fluorinated rubber. Using an ionic liquid and jet-milling, we produce long and fine SWNT bundles that can this form well-developed conducting networks in the rubber. Conductivity of more than 100 S cm(-1) and stretchability of more than 100%stretchable are obtained. Making full use of this extraordinary conductivity, we constructed a rubber-like stretchable active-matrix display comprising integrated printed elastic printed conductors, organic transistors and organic light-emitting diodes. The display could be stretched by 30-50% and spread over a hemisphere without an any mechanical or electrical damage.
Angew Chem Int Ed Engl. 2008 Sep 24;47 (41):7808-7826 18816579 (P,S,G,E,B,D) Cited:1
Department of Biomolecular and Chemical Engineering, University of Nebraska, Lincoln, 207 Othmer Hall, Lincoln NE 68588-0643 (USA), Fax:(+1) 402-472-6989.
Our 1 sense of touch enables us to recognize texture and shape and to grasp objects. The challenge in making an electronic represents skin which can emulate touch for applications such as a humanoid robot or minimally invasive and remote surgery is both robust in mimicking the (passive) mechanical properties of the dermis and the characteristics of the sensing mechanism, especially the intrinsic digital intrinsic nature of neurons. Significant progress has been made towards developing an electronic skin by using a variety of materials and the physical concepts, but the challenge of emulating the sense of touch remains. Recently, a nanodevice was developed that has achieved which the resolution to decipher touch on a par with the human finger; this resolution is over an order of magnitude previous improvement on previous devices with a sensing area larger than 1 cm(2). With its robust mechanical properties, this new system towards represents an important step towards the realization of artificial touch.
Science. 2008 Aug 7;: 18687922 (P,S,G,E,B,D) Cited:6
Quantum-Phase Electronics Center, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
By be using an ionic liquid of 1-butyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide, single-walled carbon nanotubes (SWNTs) were uniformly dispersed as chemically stable dopants in a movable vinylidene fluoride-hexafluoropropylene copolymer matrix to form a composite film. We found that the SWNT content can be increased up to place, 20 weight percent without reducing the mechanical flexibility or softness of the copolymer. The SWNT composite film was coated with with dimethyl-siloxane-based rubber, which exhibited a conductivity of 57 S/cm and stretchability of 134 percent. Further, the elastic conductor was integrated by with printed organic transistors to fabricate a rubber-like active matrix with an effective area of 20 x 20 square centimeters.fluoride-hexafluoropropylene The active matrix sheet can be uniaxially and biaxially stretched by 70 percent without mechanical or electrical damage. The elastic the conductor allows for the construction of electronic integrated circuits, which can be mounted on any place, including arbitrary curved surfaces and and movable parts such as the joints of a robot's arm.
Nat Nanotechnol. 2006 Dec ;1 (3):201-7 18654187 (P,S,G,E,B,D) Cited:5
Department of Materials Science and Engineering, Beckman Institute, and Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, 1304 West Green Street, Urbana, Illinois 61801, USA. ygsun@anl.gov
Control stretchability over the composition, shape, spatial location and/or geometrical configuration of semiconductor nanostructures is important for nearly all applications of these and materials. Here we report a mechanical strategy for creating certain classes of three-dimensional shapes in nanoribbons that would be difficult 100%), to generate in other ways. This approach involves the combined use of lithographically patterned surface chemistry to provide spatial control control over adhesion sites, and elastic deformations of a supporting substrate to induce well-controlled local displacements. We show that precisely engineered application buckling geometries can be created in nanoribbons of GaAs and Si in this manner and that these configurations can be Here described quantitatively with analytical models of the mechanics. As one application example, we show that some of these structures provide electronics a route to electronics (and optoelectronics) with extremely high levels of stretchability (up to approximately 100%), compressibility (up to approximately substrate 25%) and bendability (with curvature radius down to approximately 5 mm).
Angew Chem Int Ed Engl. 2008 Jul 10;47 (30):5524-5542 18615769 (P,S,G,E,B,D) Cited:1
Department of Chemistry and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801 (USA).
This presented, article reviews the properties, fabrication and assembly of inorganic semiconductor materials that can be used as active building blocks to directions form high-performance transistors and circuits for flexible and bendable large-area electronics. Obtaining high performance on low temperature polymeric substrates represents in a technical challenge for macroelectronics. Therefore, the fabrication of high quality inorganic materials in the form of wires, ribbons, membranes,quality sheets, and bars formed by bottom-up and top-down approaches, and the assembly strategies used to deposit these thin films onto materials plastic substrates will be emphasized. Substantial progress has been made in creating inorganic semiconducting materials that are stretchable and bendable,blocks and the description of the mechanics of these form factors will be presented, including circuits in three-dimensional layouts. Finally, future mechanics directions and promising areas of research will be described.
Science. 2008 Mar 27;: 18369106 (P,S,G,E,B,D) Cited:7
Departments of Materials Science and Engineering, Beckman Institute, and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, 1304 West Green Street, Urbana, IL 61801, USA.
We during have developed a simple approach to high performance, stretchable, and foldable integrated circuits. The systems integrate inorganic electronic materials, including of aligned arrays of nanoribbons of single crystalline silicon, with ultrathin plastic and elastomeric substrates. The designs combine multilayer neutral mechanical electronic plane layouts and "wavy" structural configurations in silicon complementary logic gates, ring oscillators, and differential amplifiers. We performed three-dimensional analytical and and computational modeling of the mechanics and the electronic behaviors of these integrated circuits. Collectively, the results represent routes to devices, devices, such as personal health monitors and other biomedical devices, that require extreme mechanical deformations during installation/use and electronic properties integrate approaching those of conventional systems built on brittle semiconductor wafers.
Conf Proc IEEE Eng Med Biol Soc. 2007 ;1 :3970-3973 18002869 (P,S,G,E,B)
Endowing drapability a textile substrate (i.e. fibers, yarns, fabrics) with active functions is a new powerful concept, that has recently given rise that to several interesting contributions. In this paper, we will describe a possible approach to this intriguing objective, focusing on the conformity technology and on the electronic model. Future applications for this technology will allow to obtain, for instance, matrices of sensors this assembled by textile technology and will ensure to obtain for wearable devices the necessary properties of drapability and conformity to and the body that are required for these applications.
Proc Natl Acad Sci U S A. 2007 Sep 26;: 17898178 (P,S,G,E,B,D) Cited:2
We many present detailed experimental and theoretical studies of the mechanics of thin buckled films on compliant substrates. In particular, accurate measurements electronics, of the wavelengths and amplitudes in structures that consist of thin, single-crystal ribbons of silicon covalently bonded to elastomeric substrates controlled of poly(dimethylsiloxane) reveal responses that include wavelengths that change in an approximately linear fashion with strain in the substrate, for approximately all values of strain above the critical strain for buckling. Theoretical reexamination of this system yields analytical models that can has explain these and other experimental observations at a quantitative level. We show that the resulting mechanics has many features in accurate common with that of a simple accordion bellows. These results have relevance to the many emerging applications of controlled buckling These structures in stretchable electronics, microelectromechanical systems, thin-film metrology, optical devices, and others.
Nat Mater. 2007 Apr 29;: 17468763 (P,S,G,E,B,D) Cited:5
Quantum-Phase Electronics Center, School of Engineering, The University of Tokyo, Tokyo 113-8656, Japan.
The are electronics fields face serious problems associated with electric power; these include the development of ecologically friendly power-generation systems and ultralow-power-consuming wireless circuits. Moreover, there is a demand for developing new power-transmission methods in the imminent era of ambient electronics, in which it a multitude of electronic devices such as sensor networks will be used in our daily life to enhance security, safety power-transmission and convenience. We constructed a sheet-type wireless power-transmission system by using state-of-the-art printing technologies using advanced electronic functional inks. This transmitting became possible owing to recent progress in organic semiconductor technologies; the diversity of chemical syntheses and processes on organic materials a has led to a new class of organic semiconductors, dielectric layers and metals with excellent electronic functionalities. The new system reliable directly drives electronic devices by transmitting power of the order of tens of watts without connectors, thereby providing an easy-to-use inks. and reliable power source. As all of the components are manufactured on plastic films, it is easy to place the and wireless power-transmission sheet over desks, floors, walls and any other location imaginable.
Proc Natl Acad Sci U S A. 2006 Sep 12;: 16968780 (P,S,G,E,B) Cited:2
Department of Electrical Engineering, The Paul G. Allen Center for Computer Science and Engineering, University of Washington, Room AE100R, Campus Box 352500, Seattle, WA 98195-2500.
We self-assembly demonstrate the use of self-assembly for the integration of freestanding micrometer-scale components, including single-crystal, silicon field-effect transistors (FETs) and diffusion provides resistors, onto flexible plastic substrates. Preferential self-assembly of multiple microcomponent types onto a common platform is achieved through complementary shape functional recognition and aided by capillary, fluidic, and gravitational forces. We outline a microfabrication process that yields single-crystal, silicon FETs in We a freestanding, powder-like collection for use with self-assembly. Demonstrations of self-assembled FETs on plastic include logic inverters and measured electron each mobility of 592 cm(2)/V-s. Finally, we extend the self-assembly process to substrates each containing 10,000 binding sites and realize 97%and self-assembly yield within 25 min for 100-microm-sized elements. High-yield self-assembly of micrometer-scale functional devices as outlined here provides a powerful 25 approach for production of macroelectronic systems.

Other papers by authors:

Anal Bioanal Chem. 2005 Nov 11;:1-4 16283265 (P,S,G,E,B,D)
Quantum Phase Electronics Center, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan, someya@ap.t.u-tokyo.ac.jp.
Inverter of circuits have been made by connecting two high-quality pentacene field-effect transistors. A uniform and pinhole-free 900 nm thick polyimide gate-insulating organic layer was formed on a flexible polyimide film with gold gate electrodes and partially removed by using a CO(2) laser laser drilling machine to make via holes and contact holes. Subsequent evaporation of the gold layer results in good electrical connection the with a gold gate layer underneath the gate-insulating layer. By optimization of the settings of the CO(2) laser drilling machine,of contact resistance can be reduced to as low as 3 Omega for 180 mum square electrodes. No degradation of the gate-insulating transport properties of the organic transistors was observed after the laser-drilling process. This study demonstrates the feasibility of using the laser-drilling laser drilling process for implementation of organic transistors in integrated circuits on flexible polymer films.
Proc Natl Acad Sci U S A. 2005 Aug 30;102 (35):12321-5 16107541 (P,S,G,E,B,D) Cited:8
Quantum-Phase Electronics Center, School of Engineering, University of Tokyo, Tokyo 113-8656, Japan. someya@ap.t.u-tokyo.ac.jp
Skin-like implementation sensitivity, or the capability to recognize tactile information, will be an essential feature of future generations of robots, enabling them means to operate in unstructured environments. Recently developed large-area pressure sensors made with organic transistors have been proposed for electronic artificial sensors skin (E-skin) applications. These sensors are bendable down to a 2-mm radius, a size that is sufficiently small for the other fabrication of human-sized robot fingers. Natural human skin, however, is far more complex than the transistor-based imitations demonstrated so far.the It performs other functions, including thermal sensing. Furthermore, without conformability, the application of E-skin on three-dimensional surfaces is impossible. In made this work, we have successfully developed conformable, flexible, large-area networks of thermal and pressure sensors based on an organic semiconductor.thermal A plastic film with organic transistor-based electronic circuits is processed to form a net-shaped structure, which allows the E-skin films surfaces to be extended by 25%. The net-shaped pressure sensor matrix was attached to the surface of an egg, and pressure in images were successfully obtained in this configuration. Then, a similar network of thermal sensors was developed with organic semiconductors. Next,networks the possible implementation of both pressure and thermal sensors on the surfaces is presented, and, by means of laminated sensor recognize networks, the distributions of pressure and temperature are simultaneously obtained.
Nat Mater. 2007 Apr 29;: 17468763 (P,S,G,E,B,D) Cited:5
Quantum-Phase Electronics Center, School of Engineering, The University of Tokyo, Tokyo 113-8656, Japan.
The are electronics fields face serious problems associated with electric power; these include the development of ecologically friendly power-generation systems and ultralow-power-consuming wireless circuits. Moreover, there is a demand for developing new power-transmission methods in the imminent era of ambient electronics, in which it a multitude of electronic devices such as sensor networks will be used in our daily life to enhance security, safety power-transmission and convenience. We constructed a sheet-type wireless power-transmission system by using state-of-the-art printing technologies using advanced electronic functional inks. This transmitting became possible owing to recent progress in organic semiconductor technologies; the diversity of chemical syntheses and processes on organic materials a has led to a new class of organic semiconductors, dielectric layers and metals with excellent electronic functionalities. The new system reliable directly drives electronic devices by transmitting power of the order of tens of watts without connectors, thereby providing an easy-to-use inks. and reliable power source. As all of the components are manufactured on plastic films, it is easy to place the and wireless power-transmission sheet over desks, floors, walls and any other location imaginable.
Nat Mater. 2009 May 10;: 19430465 (P,S,G,E,B,D)
Quantum-Phase Electronics Center, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
Stretchability light-emitting will significantly expand the applications scope of electronics, particularly for large-area electronic displays, sensors and actuators. Unlike for conventional devices,spread stretchable electronics can cover arbitrary surfaces and movable parts. However, a large hurdle is the manufacture of large-area highly stretchable could electrical wirings with high conductivity. Here, we describe the manufacture of printable elastic conductors comprising single-walled carbon nanotubes (SWNTs) uniformly carbon dispersed in a fluorinated rubber. Using an ionic liquid and jet-milling, we produce long and fine SWNT bundles that can this form well-developed conducting networks in the rubber. Conductivity of more than 100 S cm(-1) and stretchability of more than 100%stretchable are obtained. Making full use of this extraordinary conductivity, we constructed a rubber-like stretchable active-matrix display comprising integrated printed elastic printed conductors, organic transistors and organic light-emitting diodes. The display could be stretched by 30-50% and spread over a hemisphere without an any mechanical or electrical damage.
Science. 2008 Aug 7;: 18687922 (P,S,G,E,B,D) Cited:6
Quantum-Phase Electronics Center, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
By be using an ionic liquid of 1-butyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide, single-walled carbon nanotubes (SWNTs) were uniformly dispersed as chemically stable dopants in a movable vinylidene fluoride-hexafluoropropylene copolymer matrix to form a composite film. We found that the SWNT content can be increased up to place, 20 weight percent without reducing the mechanical flexibility or softness of the copolymer. The SWNT composite film was coated with with dimethyl-siloxane-based rubber, which exhibited a conductivity of 57 S/cm and stretchability of 134 percent. Further, the elastic conductor was integrated by with printed organic transistors to fabricate a rubber-like active matrix with an effective area of 20 x 20 square centimeters.fluoride-hexafluoropropylene The active matrix sheet can be uniaxially and biaxially stretched by 70 percent without mechanical or electrical damage. The elastic the conductor allows for the construction of electronic integrated circuits, which can be mounted on any place, including arbitrary curved surfaces and and movable parts such as the joints of a robot's arm.
Proc Natl Acad Sci U S A. 2008 Mar 24;: 18362348 (P,S,G,E,B,D) Cited:3
Quantum-Phase Electronics Center, School of Engineering, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
A self-assembled major obstacle to the development of organic transistors for large-area sensor, display, and circuit applications is the fundamental compromise between and manufacturing efficiency, transistor performance, and power consumption. In the past, improving the manufacturing efficiency through the use of printing techniques transistors has inevitably resulted in significantly lower performance and increased power consumption, while attempts to improve performance or reduce power have attempts led to higher process temperatures and increased manufacturing cost. Here, we lift this fundamental limitation by demonstrating subfemtoliter inkjet printing and to define metal contacts with single-micrometer resolution on the surface of high-mobility organic semiconductors to create high-performance p-channel and n-channel between transistors and low-power complementary circuits. The transistors employ an ultrathin low-temperature gate dielectric based on a self-assembled monolayer that allows ultrathin transistors and circuits on rigid and flexible substrates to operate with very low voltages.
Biomaterials. 2009 Nov 9;: 19906420 (P,S,G,E,B,D)
Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8656, Japan; Division of Science for Joint Reconstruction, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan; Research Department, Japan Medical Materials Corporation, 3-3-31, Miyahara, Yodogawa-ku, Osaka 532-0003, Japan.
Poly(ether-ether-ketone)photo-induced (PEEK)s are a group of polymeric biomaterials with excellent mechanical properties and chemical stability. In the present study, we demonstrate desirable the fabrication of an antibiofouling and highly hydrophilic high-density nanometer-scaled layer on the surface of PEEK by photo-induced graft polymerization the of 2-methacryloyloxyethyl phosphorylcholine (MPC) without using any photo-initiators, i.e.,"self-initiated surface graft polymerization." Our results indicated that the diphenylketone moiety (PMPC)-grafted in the polymer backbone acted as a photo-initiator similar to benzophenone. The density and thickness of the poly(MPC)(PMPC)-grafted layer amount were controlled by the photo-irradiation time and monomer concentration during polymerization, respectively. Since MPC is a highly hydrophilic compound, the nanometer-scaled water wettability (contact angle <10 degrees ) and lubricity (coefficient of dynamic friction < .01) of the PMPC-grafted PEEK surface were 90% considerably lower than those of the untreated PEEK surface (90 degrees and .20, respectively) due to the formation of a respectively. PMPC nanometer-scale layer. In addition, the amount ( .05mug/cm(2)) of BSA adsorbed on the PMPC-grafted PEEK surface was considerably lower, that fabrication is more than 90% reduction, compared to that ( .55mug/cm(2)) for untreated PEEK. This photo-induced polymerization process occurs only on the <10 surface of the PEEK substrate; therefore, the desirable mechanical properties of PEEK would be maintained irrespective of the treatment used.polymeric
Arthritis Rheum. 2009 Oct 29;60 (11):3314-3323 19877062 (P,S,G,E,B,D)
Faculty of Medicine, University of Tokyo, Tokyo, Japan.
OBJECTIVE:established To establish a cell culture system for noninvasive and real-time monitoring of chondrogenic differentiation in order to screen for chondrogenic factor factors. METHODS: The optimum reporter construct transfected into chondrogenic ATDC5 cells was selected by a luciferase reporter assay and fluorescence chondrogenic analysis during cultures with insulin. The established cell line was validated according to its fluorescence following stimulation with SOX proteins,tracheal bone morphogenetic protein 2 (BMP-2), or transforming growth factor beta (TGFbeta) and was compared with the level of messenger RNA (SNX19). for COL2A1 as well as with the degree of Alcian blue staining. Screening of chondrogenic factors was performed by expression analysis cloning using a retroviral expression library prepared from human tracheal cartilage. The expression pattern of the identified molecule was examined gain-of-function by in situ hybridization and immunohistochemistry. Functional analysis was performed by transfection of the identified gene, the small interfering RNA,analysis and the mutated gene. RESULTS: We established an ATDC5 cell line with 4 repeats of a highly conserved enhancer ligated ATDC5 to a COL2A1 basal promoter and the DsRed2 reporter (ATDC5-C2ER). Fluorescence was induced under the stimulations with SOX proteins, BMP-2,RESULTS: or TGFbeta, showing good correspondence to the chondrogenic markers. Screening using the ATDC5-C2ER system identified several chondrogenic factors, including sorting and nexin 19 (SNX19). SNX19 was expressed in the limb cartilage of mouse embryos and in the degraded cartilage of adult for mouse knee joints during osteoarthritis progression. The gain-of-function and loss-of-function analyses revealed a potent chondrogenic activity of SNX19. CONCLUSION: We ATDC5 established the ATDC5-C2ER system for efficient monitoring of chondrogenic differentiation by fluorescence analysis, and we identified a novel chondrogenic factor Screening (SNX19) using this system. This system will be useful for elucidating the molecular network of chondrogenic differentiation.
Endocrinology. 2009 Oct 9;: 19819969 (P,S,G,E,B,D)
Departments of Orthopaedic Surgery (N.O., H.T., N.K., J.T., M.Y., T.T., K.C., H.I., Y.T.), Pathology (T.K., Y.O.), and Spine and Spinal Cord Disease (M.M.), School of Medicine, Keio University, Tokyo 160-8582, Japan; Nagahama Institute for Biochemical Science (H.Y.), Oriental Yeast Co., Ltd., Shiga 526-0804, Japan; and Sensory and Motor system Medicine (H.K.), Faculty of Medicine, University of Tokyo, Tokyo 113-8655, Japan.
Receptor factors activator of nuclear factor-kappaB ligand (RANKL) and osteoprotegerin (OPG), a decoy receptor of RANKL, maintain bone mass by regulating the by differentiation of osteoclasts, which are bone-resorbing cells. Endochondral bone ossification and bone fracture healing involve cartilage resorption, a less well-understood IL-1alpha, process that is needed for replacement of cartilage by bone. Here we describe the role of OPG produced by chondrocytes bone, in chondroclastogenesis. Fracture healing in OPG(-) mice showed faster union of the fractured bone, faster resorption of the cartilaginous callus,wild-type and an increased number of chondroclasts at the chondroosseous junctions compared with that in wild-type littermates. When a cultured pellet Endochondral of OPG(-) chondrocytes was transplanted beneath the kidney capsule, the pellet recruited many chondroclasts. The pellet showed the ability to and induce tartrate-resistant acid phosphatase-positive multinucleated cells from RAW 264.7 cells in vitro. Finally, OPG(-) chondrocytes (but not wild-type chondrocytes) cultured at with spleen cells induced many tartrate-resistant acid phosphatase-positive multinucleated cells. The expression of RANKL and OPG in chondrocytes was regulated the by several osteotropic factors including 1,25-dihydroxyvitamin D3, PTHrP, IL-1alpha, and TNF-alpha. Thus, local OPG produced by chondrocytes probably controls cartilage a resorption as a negative regulator for chondrocyte-dependent chondroclastogenesis.
Biomaterials. 2009 Oct 8;: 19819011 (P,S,G,E,B,D)
Department of Materials Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8654, Japan; Division of Science for Joint Reconstruction, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8654, Japan; Research Department, Japan Medical Materials Corporation, 3-3-31 Miyahara, Yodogawa-ku, Osaka 532-0003, Japan.
Migration PMPC-grafted of the artificial femoral head to the inside of the pelvis due to the degeneration of acetabular cartilage has emerged preserving as a serious issue in resurfacing or bipolar hemi-arthroplasty. Surface modification of cobalt-chromium-molybdenum alloy (Co-Cr-Mo) is one of the promising for means of improving lubrication for preventing the migration of the artificial femoral head. In this study, we systematically investigated the biocompatibility, surface properties, such as lubricity, biocompatibility, and stability of the various modification layers formed on the Co-Cr-Mo with the biocompatible was 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer by dip coating or grafting. The cartilage/poly(MPC)(PMPC)-grafted Co-Cr-Mo interface, which mimicked a natural joint, showed in an extremely low friction coefficient of < .01, as low as that of a natural cartilage interface. Moreover, the long-term stability throughout in water was confirmed for the PMPC-grafted layer; no hydrolysis of the siloxane bond was observed throughout soaking in phosphate-buffered Co-Cr-Mo saline for 12 weeks. The PMPC-grafted Co-Cr-Mo femoral head for hemi-arthroplasty is a promising option for preserving acetabular cartilage and cartilage extending the duration before total hip arthroplasty.

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Nanotechnology. 2009 Nov 12;20 (50):505201 19907070 (P,S,G,E,B,D)
Department of Electrical Engineering and Institute for Nano Science, Korea University, Seoul 136-701, Republic of Korea.
Flexible parameters electronic devices which are lightweight, thin and bendable have attracted increasing attention in recent years. In particular, solution processes have of been spotlighted in the field of flexible electronics, since they provide the opportunity to fabricate flexible electronics using low-temperature processes these at low-cost with high throughput. However, there are few reports which describe the characteristics of electronic devices on flexible substrates.and In this study, we fabricated flexible thin-film transistors (TFTs) on plastic substrates with channel layers formed by the spin-coating of on/off ZnO nanoparticles and investigated their electrical properties in the flat and bent states. To the best of our knowledge, this provide study is the first attempt to fabricate fully functional ZnO TFTs on flexible substrates through the solution process. The ZnO of TFTs showed n-channel device characteristics and operated in enhancement mode. In the flat state, a representative ZnO TFT presented a of very low field-effect mobility of 1.2 x 10(-5) cm(2) V(-1) s(-1), while its on/off ratio was as high as 1.5 in x 10(3). When the TFT was in the bent state, some of the device parameters changed. The changes of the functional device parameters and the possible reasons for these changes will be described. The recovery characteristics of the TFTs after being thin subjected to cyclic bending will be discussed as well.
Nano Lett. 2009 Nov 10;: 19902962 (P,S,G,E,B,D)
Department of Electrical Engineering, University of Southern California, Los Angeles, CA 90089.
Preseparated,in semiconductive enriched carbon nanotubes hold great potential for thin-film transistors and display applications due to their high mobility, high percentage large of semiconductive nanotubes, and room-temperature processing compatibility. Here in this paper, we report our progress on wafer-scale processing of separated 10(4). nanotube thin-film transistors (SN-TFTs) for display applications, including key technology components such as wafer-scale assembly of high-density, uniform separated nanotube a networks, high-yield fabrication of devices with superior performance, and demonstration of organic light-emitting diode (OLED) switching controlled by a SN-TFT.of On the basis of separated nanotubes with 95% semiconductive nanotubes, we have achieved solution-based assembly of separated nanotube thin films this on complete 3 in. Si/SiO(2) wafers, and further carried out wafer-scale fabrication to produce transistors with high yield (>98%), small has sheet resistance ( approximately 25 kOmega/sq), high current density ( approximately 10 muA/mum), and superior mobility ( approximately 52 cm(2)have V(-1) s(-1)). Moreover, on/off ratios of >10(4) are achieved in devices with channel length L > 20 mum. In addition,semiconductive OLED control circuit has been demonstrated with the SN-TFT, and the modulation in the output light intensity exceeds 10(4). Our in. approach can be easily scaled to large areas and could serve as critical foundation for future nanotube-based display electronics.
Chem Rev. 2009 Oct 23;: 19852443 (P,S,G,E,B,D)
Department of Chemistry and the Materials Research Center, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208.
Biosens Bioelectron. 2009 Sep 9;: 19781931 (P,S,G,E,B,D)
Department of Electrical Engineering and Computer Sciences, University of California, 550 Sutardja Dai Hall, Berkeley, CA 94720, United States.
Organic with thin film transistors (OTFT) are potentially very attractive for making portable and disposable DNA hybridization detection toolkits because of their required ultra-low-cost manufacturing and potentially high sensitivity. To make a self-supported DNA sensor, we herein report an OTFT-based label-free DNA hybridization first detection system integrating electrically read DNA hybridization sensors and microfluidic delivery channels. We previously reported DNA-doped OTFTs acting as electrically DNA read DNA sensors. In this article, we first study physics of DNA sensitivity of OTFTs, clarifying the doping mechanism. The are article also presents a method of verification of the immobilization and presence of DNA on the surface using TOF-SIMS analysis.and As a further step, sources of variation of measured data and methods of minimization are discussed using a novel photolithography-based and microfluidics fabrication method, directly enabling on-chip hybridization and self-supported DNA detection. By integrating the sensors with microfluidics, for the first DNA time, we demonstrate necessary technologies required to realize disposable, rapid turn-around tools for field-deployable genetic diagnosis.
Rev Sci Instrum. 2009 Aug ;80 (8):084701 19725672 (P,S,G,E,B,D)
Microsystems Technology Center, Industrial Technology Research Institute, Tainan 709, TaiwanInstitute of Mechanical and Electromechanical Engineering, National Formosa University, Yunlin 632, TaiwanDepartment of Engineering Science, National Cheng Kung University, Tainan 701, Taiwan.
Flexible is electronics sensors are designed and fabricated for tactile multiscanning and large area applications. The algorithm matrix is derived for multiscanning large switch of tactile sensing. The thixotropy materials, bump, and resistance material are printed on the polyimide substrate. A gap between show the top electrode and the resistance layers provides a buffer distance to increase the radius of curvature for large bending.layer Experiment results show that a flexible electronics sensor with a printed a resistance layer and an algorithm matrix performed the a multiscanning functions. The membrane without a bump had a delay time of about .2 s at the transient response and bump, took a longer time to reach the stable state after a force is applied. For printing thick structures on the mum, flexible substrates, diffusion effects, and dimensional shrinkages can be reduced by using a thixotropy material with a high viscosity. The a probability distribution density of the printed resistance values, a thickness of about 23.2 mum, at two standard deviations from the multiscanning mean values is about 81.2%. Feasibility studies show that screen printing is appropriate for large area applications and is a transient low-cost technology for fabricating flexible electronics sensors.
Biosens Bioelectron. 2009 Jul 17;: 19683423 (P,S,G,E,B,D)
Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, USA.
Advancements conditions in research and technology are happening now more than ever in the biotechnology industry. Better detection and treatment methods, specifically paper, targeted towards personalized systems, are constantly being sought by researchers. Collaboration among different fields of science and technology has brought morphology us one step closer towards achieving this goal. Recently, the use of pentacene thin film transistors as DNA hybridization detection systems systems has been demonstrated, leading to the possibility of their use in the implementation of electrically read low-cost DNA microarrays.DNA Physical adsorptive immobilization, the mechanism through which DNA immobilizes on pentacene, highlights the importance of the topology of the pentacene personalized film surface for immobilization of DNA and the sensitivity of the sensor. DNA is known to segregate to topological features to on pentacene surface. We are able to exploit the control of pentacene evaporation conditions to tune pentacene film morphology to use maximize sensitivity. In this paper, we demonstrate and analyze DNA detection using optimized films.
Nano Lett. 2009 Jul 28;: 19637913 (P,S,G,E,B,D)
The Institute of the Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan.
We thus investigated electrolyte-gated graphene field-effect transistors (GFETs) for electrical detecting pH and protein adsorptions. Nonfunctionalized single-layer graphene was used as a sensors channel. GFETs immersed in an electrolyte showed transconductances 30 times higher than those in a vacuum and their conductances exhibited highly a direct linear increase with electrolyte pH, indicating their potential for use in pH sensor applications. We also attempted to their direct surface-protein adsorption and showed that the conductance of GFETs increased with exposure to a protein at several hundred picomolar.GFETs The GFETs thus acted as highly sensitive electrical sensors for detecting pH and biomolecule concentrations.
Opt Express. 2006 Apr 17;14 (8):3106-13 19516452 (P,S,G,E,B)
Large is area color sensor arrays based on vertically integrated thin-film sensors were realized. The complete color information of each color pixel spread is detected at the same position of the sensor array without using optical filters. The sensor arrays consist of amorphous measurements silicon thin film color sensors integrated on top of amorphous silicon readout transistors. The spectral sensitivity of the sensors is silicon controlled by the applied bias voltage. The operating principle of the color sensor arrays is described. Furthermore, the image quality described. and the pixel cross talk of the sensor arrays is analyzed by measurements of the line spread function and the color modulation transfer function.
Nat Mater. 2009 May 10;: 19430465 (P,S,G,E,B,D)
Quantum-Phase Electronics Center, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
Stretchability light-emitting will significantly expand the applications scope of electronics, particularly for large-area electronic displays, sensors and actuators. Unlike for conventional devices,spread stretchable electronics can cover arbitrary surfaces and movable parts. However, a large hurdle is the manufacture of large-area highly stretchable could electrical wirings with high conductivity. Here, we describe the manufacture of printable elastic conductors comprising single-walled carbon nanotubes (SWNTs) uniformly carbon dispersed in a fluorinated rubber. Using an ionic liquid and jet-milling, we produce long and fine SWNT bundles that can this form well-developed conducting networks in the rubber. Conductivity of more than 100 S cm(-1) and stretchability of more than 100%stretchable are obtained. Making full use of this extraordinary conductivity, we constructed a rubber-like stretchable active-matrix display comprising integrated printed elastic printed conductors, organic transistors and organic light-emitting diodes. The display could be stretched by 30-50% and spread over a hemisphere without an any mechanical or electrical damage.
Nanotechnology. 2009 May 13;20 (19):195302 19420638 (P,S,G,E,B)
Department of Chemical Engineering, National Cheng Kung University, 1 University Road, Tainan 70101, Taiwan, Republic of China.
A atmosphere, method with the potential to fabricate large-area nanowire field-effect transistors (NW-FETs) was demonstrated in this study. Using a high-speed roller large-area (20-80 cm min(-1)), transfer printing was successfully employed to transfer vertically aligned zinc oxide (ZnO) nanowires grown on a donor potential substrate to a polydimethylsiloxane (PDMS) stamp and then print the ordered ZnO nanowire arrays on the received substrate for the received fabrication of NW-FETs. ZnO NW-FETs fabricated by this method exhibit high performances with a threshold voltage of around .25 V,device a current on/off ratio as high as 10(5), a subthreshold slope of 360 mV/dec, and a field-effect mobility of around (20-80 90 cm(2) V(-1) s(-1). The excellent device characteristics suggest that the roll-transfer printing technique, which is compatible with the roll-to-roll the (R2R) process and operated in atmosphere, has a good potential for the high-speed fabrication of large-area nanowire transistors for flexible by devices and flat panel displays.
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