This study explored the validity of an attentional account for the involvement of the left intraparietal sulcus (IPS) in visual STM tasks. This account considers that during STM tasks, the IPS acts as an attentional modulator, maintaining activation in long-term memory networks that underlie the initial perception and processing of the specific information to be retained. In a recognition STM paradigm, we presented sequences of unfamiliar faces and instructed the participants to remember different types of information: either the identity of the faces or their order of presentation. We hypothesized that, if the left IPS acts as an attentional modulator, it should be active in both conditions, but connected to different neural networks specialized in serial order or face identity processing. Our results showed that the left IPS was activated during both order and identity encoding conditions, but for different reasons. During order encoding, the left IPS showed functional connectivity with order processing areas in the right IPS, bilateral premotor and cerebellar cortices, reproducing earlier results obtained in a verbal STM experiment. During identity encoding, the left IPS showed preferential functional connectivity with right temporal, inferior parietal and medial frontal areas involved in detailed face processing. These results not only support an attentional account of left IPS involvement in visual STM, but given their similarity with previous results obtained for a verbal STM task, they further highlight the importance of the left IPS as an attentional modulator in a variety of STM tasks.

In humans, some evidence suggests that there are two different types of spindles during sleep, which differ by their scalp topography and possibly some aspects of their regulation. To test for the existence of two different spindle types, we characterized the activity associated with slow (11-13 Hz) and fast (13-15 Hz) spindles, identified as discrete events during non-rapid eye movement sleep, in non-sleep-deprived human volunteers, using simultaneous electroencephalography and functional MRI. An activation pattern common to both spindle types involved the thalami, paralimbic areas (anterior cingulate and insular cortices), and superior temporal gyri. No thalamic difference was detected in the direct comparison between slow and fast spindles although some thalamic areas were preferentially activated in relation to either spindle type. Beyond the common activation pattern, the increases in cortical activity differed significantly between the two spindle types. Slow spindles were associated with increased activity in the superior frontal gyrus. In contrast, fast spindles recruited a set of cortical regions involved in sensorimotor processing, as well as the mesial frontal cortex and hippocampus. The recruitment of partially segregated cortical networks for slow and fast spindles further supports the existence of two spindle types during human non-rapid eye movement sleep, with potentially different functional significance.

The first aim of our PET study was to replicate previous findings concerning the brain areas activated by a verbal working memory task. The second aim was to specify the neural basis of the central executive, using a task of working memory updating. Our data confirm that the lower left supramarginal gyrus and premotor area are the key regions subserving short-term verbal memory processes. They also suggest that the updating memory task is related to middorsolateral prefrontal activation, most probably responsible for the updating function of the central executive. An unexpected, predominantly right activation occurred in the inferior parietal region during the verbal memory updating task, which we related to a visuospatial strategy used to maintain the information in short-term memory. A third purpose was to explore the brain regions activated by a nonverbal, visual memory task, and our results confirm the importance of the superior occipital gyrus in the visual short-term memory.

Precise brain regions are activated when a subject gives a judgment on himself. Those are the medial parietal cortex, essentially related to episodic memory processing, and the ventromedial prefrontal cortex, recruited for evaluating the personal valence of an information. These regions are not activated in Alzheimer's disease. The decrease of awareness for own deficits in a patient with Alzheimer's disease would depend on a reduction of episodic memory capacities and a worsening of judgment for self significance.

In addition to classical visual effects, light elicits nonvisual brain responses, which profoundly influence physiology and behavior. These effects are mediated in part by melanopsin-expressing light-sensitive ganglion cells that, in contrast to the classical photopic system that is maximally sensitive to green light (550 nm), is very sensitive to blue light (470-480 nm). At present, there is no evidence that blue light exposure is effective in modulating nonvisual brain activity related to complex cognitive tasks. Using functional magnetic resonance imaging, we show that, while participants perform an auditory working memory task, a short (18 min) daytime exposure to blue (470 nm) or green (550 nm) monochromatic light (3 x 10(13) photons/cm(2)/s) differentially modulates regional brain responses. Blue light typically enhanced brain responses or at least prevented the decline otherwise observed following green light exposure in frontal and parietal cortices implicated in working memory, and in the thalamus involved in the modulation of cognition by arousal. Our results imply that monochromatic light can affect cognitive functions almost instantaneously and suggest that these effects are mediated by a melanopsin-based photoreceptor system.

This review presents neuroimaging studies that have explored the cerebral substrates of executive functioning. These studies have demonstrated that different executive functions not only recruit various frontal areas but also depend upon posterior (mainly parietal) regions. These results are in accordance with the hypothesis that executive functioning relies on a distributed cerebral network that is not restricted to anterior cerebral areas. However, there exists an important heterogeneity in the cerebral areas associated with these different processes, and also between different tasks assessing the same process. Since these discrepant results could be due to the paradigms used (subtraction designs), recent results obtained with conjunction and interaction analyses are presented, which confirm the role of parietal areas in executive functioning and also demonstrate the existence of some specificity in the neural substrates of the executive processes of updating, shifting and inhibition. Finally, functional magnetic resonance imaging studies show that the activity in cerebral areas involved in executive tasks can be transient or sustained. Consequently, to better characterize the functional role of areas associated with executive functioning, it is important to take into account not only the localization of cerebral activity but also the temporal pattern of this activity.

Using Positron Emission Tomography (PET), we investigated cerebral regions associated with the episodic recognition of words alone and words bound to contextual colours. Two modes of colour encoding were tested: incidental and intentional word-to-colour binding. Word-only recognition was associated with brain activation in a lexico-semantic left middle temporal region and in the cerebellum following an incidental colour encoding, and with brain activation in the left posterior middle frontal gyrus, right anterior cingulate and right inferior frontal gyrus following an intentional encoding. Recognition of bound features was associated with activation in left prefrontal and superior parietal regions following an incidental colour encoding, and with preferential right prefrontal cortex activation following an intentional colour encoding. Our results are in line with the hypothesis of a parietal involvement in context processing, and prefrontal areas in monitoring retrieval processes. Our results also support the hypothesis of a 'cortical asymmetry for reflective activity'(CARA).

Recent studies have demonstrated the intervention of long-term memory processes in verbal STM tasks and several cognitive models have been proposed to explain these effects. A PET study was performed in order to determine whether supplementary cerebral areas are involved when subjects have to execute short-term memory tasks for items having representations in long-term memory (in comparison to items without such representations: words vs non-words). Results indicate that verbal STM for words specifically involves the left middle temporal gyrus (BA 21) and temporo-parietal junction (BA 39). These areas can be associated with lexical and semantic processes. These results are in agreement with cognitive models that postulate the simultaneous influence of lexical and semantic long-term representations on verbal STM processes and/or a lexico-semantic buffer.

The cortical areas involved in inhibition processes were examined with positron emission tomography (PET). The tasks administered to subjects were an adaptation of the Hayling test. In the first condition (response initiation), subjects had to complete sentences with a word clearly suggested by the context, whereas in the second condition (response inhibition), subjects had to produce a word that made no sense in the context of the sentence. Results indicated that the response initiation processes were associated to increases of activity in the left inferior frontal gyrus (BA 45/47), whereas response inhibition processes led to increases in a network of left prefrontal areas, including the middle (BA 9 and BA 10) and inferior (BA 45) frontal areas.

Sensorimotor-based theories of semantic memory contend that semantic information about an object is represented in the neural substrate invoked when we perceive or interact with it. We used fMRI adaptation to test this prediction, measuring brain activation as participants read pairs of words. Pairs shared function (flashlight-lantern), shape (marble-grape), both (pencil-pen), were unrelated (saucer-needle), or were identical (drill-drill). We observed adaptation for pairs with both function and shape similarity in left premotor cortex. Further, degree of function similarity was correlated with adaptation in three regions: two in the left temporal lobe (left medial temporal lobe, left middle temporal gyrus), which has been hypothesized to play a role in mutimodal integration, and one in left superior frontal gyrus. We also found that degree of manipulation (i.e., action) and function similarity were both correlated with adaptation in two regions: left premotor cortex and left intraparietal sulcus (involved in guiding actions). Additional considerations suggest that the adaptation in these two regions was driven by manipulation similarity alone; thus, these results imply that manipulation information about objects is encoded in brain regions involved in performing or guiding actions. Unexpectedly, these same two regions showed increased activation (rather than adaptation) for objects similar in shape. Overall, we found evidence (in the form of adaptation) that objects that share semantic features have overlapping representations. Further, the particular regions of overlap provide support for the existence of both sensorimotor and amodal/multimodal representations.

Abstract Although many neuroimaging studies have considered verbal and visual short-term memory (STM) as relying on neurally segregated short-term buffer systems, the present study explored the existence of shared neural correlates supporting verbal and visual STM. We hypothesized that networks involved in attentional and executive processes, as well as networks involved in serial order processing, underlie STM for both verbal and visual list information, with neural specificity restricted to sensory areas involved in processing the specific items to be retained. Participants were presented sequences of nonwords or unfamiliar faces, and were instructed to maintain and recognize order or item information. For encoding and retrieval phases, null conjunction analysis revealed an identical fronto-parieto-cerebellar network comprising the left intraparietal sulcus, bilateral dorsolateral prefrontal cortex, and the bilateral cerebellum, irrespective of information type and modality. A network centered around the right intraparietal sulcus supported STM for order information, in both verbal and visual modalities. Modality-specific effects were observed in left superior temporal and mid-fusiform areas associated with phonological and orthographic processing during the verbal STM tasks, and in right hippocampal and fusiform face processing areas during the visual STM tasks, wherein these modality effects were most pronounced when storing item information. The present results suggest that STM emerges from the deployment of modality-independent attentional and serial ordering processes toward sensory networks underlying the processing and storage of modality-specific item information.

Abstract Although humans generally experience a coherent sense of selfhood, we can, nevertheless, articulate different aspects of self. Recent research has demonstrated that one such aspect of self-conceptual knowledge of one's own personality traits-is subserved by ventromedial prefrontal cortex (vMPFC). Here, we examined whether an alternative aspect of "self"-being an agent who acts to achieve one's own goals-relies on cognitive processes that overlap with or diverge from conceptual operationalizations of selfhood. While undergoing fMRI, participants completed tasks of both conceptual self-reference, in which they judged their own or another person's personality traits, and agentic self-reference, in which they freely chose an object or watched passively as one was chosen. The agentic task failed to modulate vMPFC, despite producing the same memory enhancement frequently observed during conceptual self-referential processing (the "self-reference" effect). Instead, agentic self-reference was associated with activation of the intraparietal sulcus (IPS), a region previously implicated in planning and executing actions. Experiment 2 further demonstrated that IPS activity correlated with later memory performance for the agentic, but not conceptual, task. These results support views of the "self" as a collection of distinct mental operations distributed throughout the brain, rather than a unitary cognitive system.

Research reveals dramatic differences in the ways that people from different cultures perceive the world around them. Individuals from Western cultures tend to focus on that which is object-based, categorically related, or self-relevant whereas people from Eastern cultures tend to focus more on contextual details, similarities, and group-relevant information. These different ways of perceiving the world suggest that culture operates as a lens that directs attention and filters the processing of the environment into memory. The present review describes the behavioral and neural studies exploring the contribution of culture to long-term memory and related processes. By reviewing the extant data on the role of various neural regions in memory and considering unifying frameworks such as a memory specificity approach, we identify some promising directions for future research.

Verbal working memory is the ability to temporarily store and manipulate verbal information. This study tested the predictions of a neuroanatomical model of how the cerebellum contributes to verbal working memory (Desmond et al., 1997). In this model, a large bilateral region in the superior cerebellum is associated with articulatory rehearsal and a right-lateralized region in the inferior cerebellum is associated with the correction of errors within the working memory system. The Desmond et al.(1997) model was based on neuroimaging findings using item recognition tasks and comparisons between working memory and covert rehearsal tasks, whereas in this functional magnetic resonance imaging (fMRI) study we used a delayed serial recall (DSR) task because it relies more heavily on articulatory rehearsal, and our comparison tasks included both overt and covert speech tasks. Our results provide some support for the Desmond et al.(1997) model. In particular, we found multiple activation foci within the superior and inferior sectors of the cerebellum and evidence that these regions show different patterns of activation across working memory and speech tasks. However, the specific patterns of activation were not fully consistent with those reported by Desmond et al.(1997). Namely, our results indicate that activation in the superior sector should be functionally subdivided into a medial focus involved in speech processing and a lateral focus more specific to verbal working memory; the results also indicate that activation in the inferior sector is not uniquely right lateralized. These complex findings speak to the need for future studies to consider the speech-motor aspects of tasks, to investigate the functional significance of adjacent peaks of activation within large regions of cerebellar activation, and to use analysis procedures that support regional distinctions through direct statistical tests. Such studies would help to refine our understanding of how the cerebellum contributes to speech and verbal working memory.

Presents a postscript to the current authors' response to the comments by J. S. Bowers, M. F. Damian, and C. J. Davis on the current authors' original article,"Short-term memory for serial order: A recurrent neural network model,". Here, Botvinick and Plaut address Bowers et al's assertions that neurophysiological studies that have reported conjunctive coding for item and order have also often reported neurons that code for item independent of order and vice versa, and that the primacy model of Page and Norris (1998) uses order-independent item representations. Botvinick and Plaut then consider the two new simulations that Bowers et al presented in their commentary, ultimately concluding that the critique by Bowers et al does little to challenge the viability of the Botvinick and Plaut model.(PsycINFO Database Record (c) 2009 APA, all rights reserved).

A central claim shared by most recent models of short-term memory (STM) is that item knowledge is coded independently from order in long-term memory (LTM; e.g., the letter A is coded by the same representational unit whether it occurs at the start or end of a sequence). Serial order is computed by dynamically binding these item codes to a separate representation of order. By contrast, Botvinick and Plaut developed a parallel distributed processing (PDP) model of STM that codes for item-order information conjunctively, such that the same letter in different positions is coded differently in LTM. Their model supports a wide range of memory phenomena, and critically, STM is better for lists that include high, as opposed to low, sequential dependencies (e.g., bigram effects). Models with context-independent item representations do not currently account for sequential effects. However, we show that their PDP model is too sensitive to these effects. A modified version of the model does better but still fails in important respects. The successes and failures can be attributed to a fundamental constraint associated with context-dependent representations. We question the viability of conjunctive coding schemes to support STM and take these findings as problematic for the PDP approach to cognition more generally.(PsycINFO Database Record (c) 2009 APA, all rights reserved).

The present functional magnetic resonance imaging study investigates the neural substrates of relative pitch. Musicians and nonmusicians performed 2 same/different discrimination tasks (simple and transposed melody) that differed in whether they required precise encoding and comparison of relative pitch structure, along with 2 control tasks (rhythm and phoneme). The transposed melody task involved a musical transposition of 4 semitones between the target and comparison patterns, requiring listeners to use interval information rather than the absolute value of the individual pitches. Contrasting the transposed melody to the simple melody condition revealed greater activation in the cortex within the intraparietal sulcus (IPS) bilaterally; control tasks did not elicit significant activity in the IPS. Moreover, a whole-brain voxel-wise regression analysis of brain oxygenation level-dependent signal showed that activity within the right IPS predicted task performance for both musicians and nonmusicians specifically in the transposed melody condition. Successful performance of the transposed melody task requires encoding and comparison of auditory patterns having different tonal reference points-thus simple tonal memory is not sufficient. Our results point to a role for the IPS in transforming high-level auditory information. We suggest that this area may support a general capacity for transformation and comparison of systematically related stimulus attributes.

We compare three models of representation of item order in a verbal STM task: item-item associations, item-position associations, and primacy gradient. A speeded probed recall task is used, in which a list of words is presented, immediately followed by a probe; participants must report as fast as possible the word that was in the probed position. In the number probe condition, a digit is presented and one must say the word in that position. In the word probe condition, the probe is an item of the list and participants must say the immediately following item. Response times (RTs) are analyzed according to probe type and position. The three models imply different predictions about RTs as a function of serial order in the two conditions. Our results suggest a serial, self-terminating search from the beginning of the list to the target position, except for the final position, which is directly accessible. The item-item and item-position association models are ruled out; the primacy gradient model accounts satisfactorily for our results, except for the finding of a larger recency effect with a number probe. Alternative interpretations are also discussed.

Word frequency and word concreteness are language attributes that have been shown to independently influence the recall of items in verbal short-term memory (STM). It has been argued that such effects are evidence for the action of long-term memory knowledge on STM traces. However, research to date has not investigated whether these variables interact in serial recall. In two experiments, we examined the behavior of these variables under factorial manipulation and demonstrated that the effect of word frequency is dependent on the level of concreteness of items. Serial recall performance is examined with reference to two explanatory approaches: Walker and Hulme's (1999) dual-redintegration account and language-based models of STM. The data indicate that language-based models are more compatible with the observed effects and challenge the view that frequency and concreteness effects in STM are the products of distinct mechanisms.